| 革兰阳性细菌AIP型群体感应抑制剂的研究进展 |
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| 引用本文： | 孔凡栋,周丽曼,马青云,黄圣卓,赵友兴.革兰阳性细菌AIP型群体感应抑制剂的研究进展[J].热带生物学报,2017,8(2). |
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| 作者姓名： | 孔凡栋 周丽曼 马青云 黄圣卓 赵友兴 |
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| 作者单位： | 中国热带农业科学院热带生物技术研究所,海口,571101 |
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| 基金项目： | 农业部公益性行业(农业)科研专项，国家自然科学基金青年科学基金项目 |
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| 摘 要： | 以自诱导肽(autoinducter peptide)AIP为信号分子的细菌群体感应(quorum sensing,QS)系统存在于多种革兰阳性细菌中,是研究新型抗金黄色葡萄球菌等革兰阳性细菌药物的重要突破口。目前发现的AIP型群体感应抑制剂(quorum sensing inhibitors,QSIs)有小分子与大分子2种类型,笔者对这2类AIP型QSIs的研究进展进行综述,为新型抗菌药物的研发提供理论依据。
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| 关 键 词： | 细菌群体感应 AIP型群体感应系统 群体感应抑制剂 研究进度 |
Research Advances in the AIP-based Quorum Sensing Inhibitors of Gram-positive Bacteria |
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| KONG Fandong,ZHOU Liman,MA Qingyun,HUANG Shengzhuo,ZHAO Youxing.Research Advances in the AIP-based Quorum Sensing Inhibitors of Gram-positive Bacteria[J].Journal of Tropical Biology,2017,8(2). |
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| Authors: | KONG Fandong ZHOU Liman MA Qingyun HUANG Shengzhuo ZHAO Youxing |
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| Abstract: | Quorum sensing (QS) is a responding phenomenon of communication between bacteria,providing a new way to study treatment of bacterial infections.The QS system with autoinducter peptides (AIPs) as signaling molecules exist in a variety of gram-positive bacteria,and is considered as an important breakthrough in development of new drugs against gram-positive bacteria,such as Staphylococcus aureus.The AIP-based quorum sensing inhibitors (QSIs) discovered so far include two types of molecule,small and macro.The recent researches in these two types of molecule in AIP based QSIs were reviewed to provide a reference for developing of new antibacterial drugs. |
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| Keywords: | Quorum sensing AIP-based quorum sensing system quorum sensing inhibitors Research advances |
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