| 酮内酯类抗生素的研究进展(英文) |
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| 引用本文： | 邵莉萍,张继瑜.酮内酯类抗生素的研究进展(英文)[J].农业科学与技术,2017,18(8). |
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| 作者姓名： | 邵莉萍 张继瑜 |
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| 作者单位： | 中国农业科学院兰州畜牧与兽药研究所/农业部兽药创制重点实验室,甘肃兰州,730050 |
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| 基金项目： | " 十二五" 国家科技支撑计划项目，国家现代农业产业技术体系专项(CAR-38).Supported by National Sci-tech Support Plant during Twelfth Five-Year Plan，Earmarked Fund for China Agriculture Research System |
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| 摘 要： | 大环内酯类抗生素以其良好的抗菌效果与高安全性,在临床上获得了广泛应用,然而其耐药菌却不断出现。为了解决病原耐药性问题,研究人员通过对大环内酯类抗生素的结构进行修饰,获得了第三代大环内酯类抗生素——酮内酯类抗生素,从而有效地解决了这一问题。酮内酯类抗生素是一种具有大环内酯结构的红霉素衍生物,其代表药物主要包括泰利菌素、喹红霉素和solithromycin等。文章简要介绍了酮内酯类抗生素的研究进展,以期对新型大环内酯类抗生素的研究开发有所帮助。
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| 关 键 词： | 大环内酯类抗生素 酮内酯类抗生素 泰利菌素 喹红霉素 solithromycin 进展 |
Research Progress of Ketolide Antibiotics |
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| Liping SHAO,Jiyu ZHANG.Research Progress of Ketolide Antibiotics[J].Agricultural Science ＆ Technology,2017,18(8). |
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| Authors: | Liping SHAO Jiyu ZHANG |
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| Abstract: | Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, scholars obtain the third generation of macrolide antibiotics, ketolide antibiotics, which are developed by modifying the structure of macrolide antibiotics, thereby efficiently solving the problem. Ketolide antibiotics are a type of erythromycin derivatives with macrolide structure, and the typical drugs mainly include telithromycin, cethromycin and solithromycin, etc . This paper briefly introduced the recent progress of ketolide antibiotics, with an attempt to provide help to the research and development of new macrolide antibiotics. |
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| Keywords: | Macrolide antibiotics Ketolide antibiotics Telithromycin Cethromycin Solithromycin Progress |
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