| 土党参多糖对环磷酰胺所致小鼠白细胞减少症的影响 |
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| 引用本文： | 姚佳,杨晓玲,彭梅,张振东,杨娟.土党参多糖对环磷酰胺所致小鼠白细胞减少症的影响[J].贵州大学学报(农业与生物科学版),2011,30(4):340-343. |
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| 作者姓名： | 姚佳 杨晓玲 彭梅 张振东 杨娟 |
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| 作者单位： | 1. 贵州大学生命科学学院,贵州贵阳550025;贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002
2. 贵州大学生命科学学院,贵州贵阳,550025 |
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| 基金项目： | 贵阳市科学技术计划项目基金[（2010）筑科农合同字第1-中-29号] |
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| 摘 要： | 研究土党参多糖(CJP)对环磷酰胺所致小鼠白细胞减少症的影响。小鼠腹腔注射环磷酰胺,建立白细胞减少模型,以高、中、低3个不同剂量的土党参多糖分别灌胃给药,测定外周血象、脏器指数、骨髓DNA。给药组与模型组比,小鼠白细胞数量明显增高(P<0.01),脾脏指数、胸腺指数差异不明显,中剂量组骨髓DNA明显增加(P<0.05)。土党参多糖对环磷酰胺所致小鼠白细胞减少症有升高白细胞和促进小鼠骨髓造血功能的作用。
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| 关 键 词： | 土党参 多糖 白细胞 红细胞 骨髓 |
Effect of Polysaccharide from Campanumoea javanica on Leucopenia Induced by Cyclophosphamide in Mice |
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| YAO Jia,YANG Xiao-ling,PENG Mei,ZHANG Zhen-dong,YANG Juan.Effect of Polysaccharide from Campanumoea javanica on Leucopenia Induced by Cyclophosphamide in Mice[J].Journal of Mountain Agriculture & Biology,2011,30(4):340-343. |
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| Authors: | YAO Jia YANG Xiao-ling PENG Mei ZHANG Zhen-dong YANG Juan |
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| Institution: | 1. College of Life Sci- ences, Guizhou University, Guiyang Guizhou 550025, China. 2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang Guizhou 550002, China) |
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| Abstract: | To investigate the effect of polysaecharides from Campanumoea javanica （CJP） on leukopenia eansed by cyclophosphamide in mice, the leukopenia model was established through intraperitoneal injection of eyelophosphamide to mice. The mice treated with polysaceharides were divided into high, medium and low dosages, and their peripheral blood, organ index and bone marrow DNA of mice were determined. Three dos- age groups of CJP demonstrated significant enhancement in the number of white blood cell （WBC）, spleen index and thymus index compared with the model group. Therefore, CJP can obviously elevate the number of white blood cells and promote of bone marrow hematopoietie function on leukopenia induced by cyelophosphamide in mice. |
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| Keywords: | Campanumoea javanica Polysaccharides WBC RBC bone marrow |
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