CRITICAL AND CONTROLLED LABORATORY TRIALS IN SHEEP WITH TETRAMISOLE |
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| Authors: | J A Hart BSc C Curr |
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| Institution: | William Cooper and Nephews Pty. Ltd., The Cooper Field Station, Luddenham Road, St. Mary's, New South Wales |
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| Abstract: | Critical and controlled anthelmintic tests were carried out using tetramisole hydrochloride per os against adult and immature gastro-entestinal nematodes of sheep. The drug was highly effective against adult Haemonchus contortus, Ostertagia spp, Trichostrongylus axei, intestinal Trichostrongylus spp, Nematodirus spp, Oesophagostomum columbi-anum and Chabertia ovina, and against 5th stage worms of the two latter species, at 10 mg/kg bodyweight and above. Efficiency against Trichuris ovis ranged from 67 to 100% at 20 mg/kg. A dose rate of 10 mg/kg was 98 to 100% effective against 14-day old H. contortus and T. axei, and against both 7-day and 14-day old intestinal Trichostrongylus spp infections, but a rate of 15 mg/kg was required for high activity against 14-day old Ostertagia spp. Seven-day old infections of H. contortus, T. axei and particularly Ostertagia spp were more resistant, and drug activity was variable at a dose rate of 15 mg/kg. Tetramisole would appear to have good activity against 7-day and 14-day old larvae of O. columbianum at 15 mg/kg in lambs in which the development of this species tended to be retarded. |
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