| MAPK信号通路介导的自噬调控破骨细胞分化的研究进展 |
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| 引用本文： | 陈苗苗,仝锡帅,刘宗平.MAPK信号通路介导的自噬调控破骨细胞分化的研究进展[J].动物医学进展,2020(2):92-97. |
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| 作者姓名： | 陈苗苗 仝锡帅 刘宗平 |
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| 作者单位： | 扬州大学兽医学院/江苏省动物重要疫病与人兽共患病防控协同创新中心 |
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| 基金项目： | 国家自然科学基金项目(31302154,31372495,31672620);教育部博士点基金新教师类项目(20133250120002);江苏高校优势学科建设工程资助项目 |
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| 摘 要： | 破骨细胞具有骨吸收活性,与骨组织稳态密切相关。丝裂原活化蛋白激酶(MAPK)通路是细胞介导胞内外刺激传导的信号通路,参与细胞的增殖、分化、自噬等多种生理过程。MAPK介导的自噬在调控破骨细胞分化中具有重要作用。探究MAPK的三条经典通路(ERK1/2、JNK及p38 MAPK信号通路)介导的自噬与破骨细胞分化之间的关系,对于寻找与破骨细胞相关的骨代谢疾病的新疗法具有重要意义。
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| 关 键 词： | 破骨细胞 丝裂原活化蛋白激酶信号通路 自噬 |
Progress on Autophagy in Regulation of Osteoclast Differentiation via MAPK Signaling Pathway |
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| CHEN Miao-miao,TONG Xi-shuai,LIU Zong-ping.Progress on Autophagy in Regulation of Osteoclast Differentiation via MAPK Signaling Pathway[J].Progress In Veterinary Medicine,2020(2):92-97. |
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| Authors: | CHEN Miao-miao TONG Xi-shuai LIU Zong-ping |
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| Institution: | (Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,College of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu,225009,China) |
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| Abstract: | Mature osteoclasts have bone resorption activity,which is closely related to the homeostasis of bone tissue.Mitogen-activated protein kinase(MAPK)pathway is a signal pathway that mediates intracellular and extracellular stimulus transduction,and is involved in cell proliferation,differentiation,autophagy and other physiological processes.Autophagy mediated by MAPK pathways plays an important role in regulation of osteoclast differentiation.Exploring the relationship between autophagy mediated by three classic MAPK pathways(ERK1/2,JNK and p38 MAPK signaling pathways)and osteoclast differentiation is of great significance for finding new therapies for osteoclast related bone metabolic diseases. |
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| Keywords: | osteoclast MAPK signaling pathway autophagy |
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