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| 高原牦牛胎盘粉对衰老模型小鼠抗氧化作用的研究I | |
| 引用本文： | 常兰,宁鹏,张寿,尚海忠,高丽英,黄敬阳.高原牦牛胎盘粉对衰老模型小鼠抗氧化作用的研究I[J].安徽农业科学,2009,37(18):8525-8526. |
| 作者姓名： | 常兰 宁鹏 张寿 尚海忠 高丽英 黄敬阳 |
| 作者单位： | 1. 青海大学农牧学院,青海西宁,810003 2. 青海省海西州兽医卫生监督所,青海海西州,817000 3. 青海省海西州动物疫病控制中心,青海海西州,817000 |
| 摘 要： | 目的]研究高原牦牛胎盘粉的抗氧化作用。方法]将健康小鼠随机分为正常对照组、模型组、阳性对照组、低海拔胎盘组、中海拔胎盘组和高海拔胎盘组，将后5组用D-半乳糖造亚急性衰老小鼠模型；低海拔胎盘组、中海拔胎盘组和高海拔胎盘组的小鼠在建模11d后每天灌胃牦牛胎盘粉40mg／只、阳性对照组每天灌服维生素E100mg／kg，45d后观察心、肝、脾、肺、肾组织中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活力和丙二醛（MDA）含量。结果]高原牦牛胎盘粉可提高小鼠心、肝、脾、肺、肾组织中SOD（P〈0.01）和GSH-Px（P〈0.01）活力，明显抑制小鼠心、肝、脾、肺、肾组织中MDA（P〈0.01）的形成。结论]高原牦牛胎盘粉有很好的抗衰老作用。 |
| 关 键 词： | D-半乳糖 高原牦牛胎盘粉 抗衰老作用 GSH-Px SOD MDA |
Study on the Anti-oxidative Effect of Plateau Yak Placenta Powder on Subacute Aging Model Mice |
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| Institution: | CHANG Lan et al (College of Agriculture and Animal Science, Xining, Qinghai 810003 ) |
| Abstract: | Objective] The purpose was to study the anti-oxidative effect of the plateau yak placenta powder on the senescent mice.Method] The healthy mice were randomly divided into normal control group,model group,positive control group,low-elevation,middle-elevation and high-elevation placenta groups.Five groups except for normal control group were used to construct subacute aging mice model by D-galactose.11 days later,the mice of the low-elevation,middle-elevation and high-elevation yak placenta powder groups were gavaged with yak placenta powder with its dose being of 400 mg/kg,respectively,positive control group were gavaged with Vitamin E 100 mg/kg.After 45 days,the content of SOD,GSH-Px,MDA in heart,liver,spleen,lung and kidney,skeleton muscle were determinated.Result] The results showed that yak placenta powder could improve activity of SOD(P<0.01) and GSH-Px(P<0.01) and obviously inhibit the formation of MDA(P<0.01) in heart,liver,spleen,lung and kidney of mice. Conclusion]The yak placenta powder has good anti-aging effect. |
| Keywords: | GSH-Px SOD MDA |
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