| 脂源性外泌体的功能及其在水生动物中的研究进展 |
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| 引用本文： | 卢荣华,吉红,聂国兴.脂源性外泌体的功能及其在水生动物中的研究进展[J].水产学报,2019,43(10):2049-2059. |
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| 作者姓名： | 卢荣华 吉红 聂国兴 |
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| 作者单位： | 河南师范大学水产学院, 河南 新乡 453007,西北农林科技大学动物科技学院, 陕西 杨凌 712100,河南师范大学水产学院, 河南 新乡 453007 |
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| 基金项目： | 国家自然科学基金（31402311，31672671，31872581）；NSFC-河南联合基金（U1704109）；河南省重点科技攻关项目（国家科技合作领域）（182102410031） |
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| 摘 要： | 外泌体是一种由多种细胞分泌的30～150 nm的小囊泡,其通过转运蛋白质、脂质、mRNAs和microRNAs等方式影响或改变受体细胞的行为,已被证明是一种细胞间通讯的新模式。研究发现外泌体参与了脂肪合成及肥胖、肝脏脂肪变性、胰岛素抵抗、免疫调节、炎症反应、肿瘤发生、血管以及神经生成和成骨等过程。本文阐述了外泌体的形成与生物学特性、分离及鉴定的方法,重点阐述了脂肪来源的外泌体在机体生理及病理过程中的潜在作用,并概述了水生动物外泌体的研究进展,以期为脂肪代谢及有关疾病的病理机制与潜在干预靶标的研究提供新的思路和途径,也为更多地了解外泌体可能在鱼类糖脂代谢紊乱中的作用提供理论基础。
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| 关 键 词： | 外泌体 功能 代谢紊乱 调控机制 研究进展 |
| 收稿时间： | 2019/9/9 0:00:00 |
| 修稿时间： | 2019/9/29 0:00:00 |
Function of adipose-derived exosomes and related research progress in aquatic animals |
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| LU Ronghu,JI hong and NIE Guoxing.Function of adipose-derived exosomes and related research progress in aquatic animals[J].Journal of Fisheries of China,2019,43(10):2049-2059. |
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| Authors: | LU Ronghu JI hong and NIE Guoxing |
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| Institution: | College of Fisheries, Henan Normal University, Xinxiang 453007, China.,College of Animal Science and Technology, Northwest A & F University, Yangling 712100, China and College of Fisheries, Henan Normal University, Xinxiang 453007, China. |
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| Abstract: | Exosome, a 30-150 nm vesicle, is secreted by a variety of cells, which influences or changes the behavior of recipient cells by transferring proteins, lipids, mRNAs and miRNAs, etc., and has been proved to be a new mode of intercellular communication. Exosomes have been found to be involved in the processes of fat synthesis and obesity, liver steatosis, insulin resistance, immune regulation, inflammatory response, tumorigenesis, vascular and neurogenesis, and osteogenesis. This article mainly expounds the formation and biological characteristics of exosomes, separation and identification method of exosomes. Moreover, it expounds the potential functions of adipose-derived exosome in the physiological and pathological process, and summarizes the research progress of exosomes in aquatic animals. It will provide new approach to lipid metabolism, pathological mechanisms of related diseases and potential intervention target. Also, it will provide basic theoretical knowledge of the role of exosome in glucose and lipid metabolism disturbance of fish. |
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| Keywords: | exosomes function metabolic disorders regulatory mechanism research progress |
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