Changes in peripheral lymphocyte subsets in the type 1 diabetic dogs treated with insulin injections |
| |
| Authors: | Mori Akihiro Sagara Fumi Shimizu Sumire Mizutani Hisashi Sako Toshinori Hirose Hisashi Yoshimura Itaru Uematsu Yosuke Yamaguchi Tomohiro Arai Toshiro |
| |
| Institution: | Department of Veterinary Science, School of Veterinary Medicine, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan. D0608@nvlu.ac.jp |
| |
| Abstract: | Plasma metabolites and peripheral lymphocyte subsets were measured in ten diabetic and ten control dogs to investigate their significances as indicators to evaluate immune states in the diabetic dogs. Diabetic dogs were treated with insulin injections, however their plasma glucose and fructosamine concentrations were significantly higher than those of the controls. There were no significant differences in counts of total white blood cells (WBC) and lymphocyte CD8(+) cells (cytotoxic T cells) between the control and the diabetic dogs. In the diabetic dogs, the counts of CD3(+) (T cells), CD4(+) (Helper T cells) and CD21(+) (B cells) cells and the peripheral lymphocytes CD4/CD8 ratio were significantly lower than those in the control dogs. We confirmed abnormality of lymphocyte subsets in insulin treated diabetic dogs and it may relate to depression of immunocompetence and high susceptibility to common infectious diseases. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
