Effect of solution and apparatus parameters on the morphology and size of electrosprayed PLGA microparticles |
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| Authors: | Abdol-Rahim Faramarzi Jalal Barzin Hamid Mobedi |
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| Institution: | 1.Biomaterials Department,Iran Polymer and Petrochemical Institute,Tehran,Iran;2.Novel Drug Delivery Systems Department,Iran Polymer and Petrochemical Institute,Tehran,Iran |
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| Abstract: | Because of a number of facilities, the Electrospray (ES) method is gaining ever-increasing popularity among researchers for producing nano-to-micron-sized particles. Microparticles (MPs) of poly lactic-co-glycolic acid (PLGA) were prepared by using the ES technique. The influence of both solution and apparatus parameters on the morphology, size, size distribution, and uniformity of produced MPs were investigated. Results of SEM images and calculations revealed that polymer concentration is a critical parameter in the ES system. In a semi-dilute moderately entangled regime, chain entanglement can easily occur. Solution flow rate is a key factor among apparatus parameters. Vapour pressure is a key parameter affecting MP morphology. The size of the particles tended to reduce with an increase in voltage. The needle gauge did not have an important impact on particle size. The role of the electric field changed at different collecting distances. Using a saturated combination of EtOH/PVA is an acceptable collecting medium for PLGA MPs. It is possible to produce uniform and spherical MPs by using chloroform as a solvent. However, a reduction in particle size is achievable by using a solvent of chloroform/DMF (90/10 w/w). |
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