| 洛克沙胂对鲫鱼暴露胁迫的毒性效应 |
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| 引用本文： | 孙永学,陈杖榴,陈展飞,刘志昌.洛克沙胂对鲫鱼暴露胁迫的毒性效应[J].华南农业大学学报,2004,25(3):101-104. |
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| 作者姓名： | 孙永学 陈杖榴 陈展飞 刘志昌 |
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| 作者单位： | 华南农业大学,广东省兽药研制与安全评价重点实验室,广东,广州,510642;华南农业大学,广东省兽药研制与安全评价重点实验室,广东,广州,510642;华南农业大学,广东省兽药研制与安全评价重点实验室,广东,广州,510642;华南农业大学,广东省兽药研制与安全评价重点实验室,广东,广州,510642 |
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| 基金项目： | 国家自然科学基金重点项目(30130140) |
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| 摘 要： | 进行了洛克沙胂对鲫鱼的急性毒性试验,通过急性暴露胁迫对抗氧化系统的影响进行了探讨.试验发现,洛克沙胂对鲫鱼的急性毒性较低,24h LC50为181.69 mg/L,48 b LC50和96 h LC50均为176.57 mg/L.30、45 mg/L(以 As计)洛克沙胂连续暴露5 d,鲫鱼脑和肝乳酸脱氢酶受到显著抑制(P<0.05)并呈剂量-效应关系.鱼脑和肝的丙二醛含量显著升高(P<0.05).鲫鱼脑、肝和鳃组织的超氧化物歧化酶活性在初期显著升高(P<0.05),但在试验后期随剂量增高而受到显著抑制(P<0.05).鱼脑谷胱甘肽-S-转移酶受到极显著的抑制(P<0.01).结果表明:洛克沙胂对鲫鱼巯基酶和抗氧化功能有明显抑制,鱼脑和肝脏氧化损伤最明显,呈现剂量-效应关系.
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| 关 键 词： | 洛克沙胂 鲫鱼 急性毒性 抗氧化系统 |
| 文章编号： | 1001-411X(2004)03-0101-04 |
Toxic effects of roxarsone on Carassias auratus |
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| SUN Yong-xue,CHEN Zhang-liu,CHEN Zhan-fei,LIU Zhi-chang.Toxic effects of roxarsone on Carassias auratus[J].Journal of South China Agricultural University,2004,25(3):101-104. |
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| Authors: | SUN Yong-xue CHEN Zhang-liu CHEN Zhan-fei LIU Zhi-chang |
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| Abstract: | Toxic effects of roxarsone were investigated when carp (Carassias auratus) was exposed to roxarsone solution of 30 and 45 mg/L for 2 and 5 days. Roxarsone showed low toxicity to carp, but the margin of safety was narrow, the LC50 were as follows: 24 h LC50 181.69 mg/L, 48 and 96 h LC50 176.57 mg/L. The activities of LDH in carp brain and carp liver were inhibited significantly (P < 0.05) and showed dose-effect relationship. The contents of MDA in carp brain and carp liver increased significantly in all treated groups (P < 0.05) . Initially the activities of SOD in carp brain, liver and gill were enhanced significantly (P< 0.05) and then inhibited markedly with increasing doses. The activities of GSH-ST in carp brain were inhibited strikingly ( P <0.01) . These results showed roxarsone could inhibit enzyme with sulfhydryl group and the ability of antiox-idation. The oxidative damage to carp were remarkable and showed dose-effect relationship. |
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| Keywords: | roxarsone carp acute toxicity antioxidation system |
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