| 人低分化鼻咽癌(CNE-2Z)细胞膜电位及其形成的离子机制 |
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| 引用本文： | 陈丽新,王立伟,曾广华,聂思槐,钟萍,郭忠民,胡新荣,唐慰萍.人低分化鼻咽癌(CNE-2Z)细胞膜电位及其形成的离子机制[J].湛江医学院学报,1993(Z1). |
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| 作者姓名： | 陈丽新 王立伟 曾广华 聂思槐 钟萍 郭忠民 胡新荣 唐慰萍 |
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| 作者单位： | 湛江医学院生理学教研室
(陈丽新，王立伟，曾广华，聂思槐，钟萍)，湛江医学院病理学教研室
(郭忠民，胡新荣)，湛江医学院病理学教研室(唐慰萍) |
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| 摘 要： | 用玻璃微电极细胞内记录方法,对体外培养的人低分化鼻咽癌(CNE-2Z)细胞膜电位及其形成机制的研究结果表明:CNE-2Z细胞膜电位与正常鼻咽上皮细胞相比,负值明显增大(P<0.01),变异系数也大,且分布弥散。CNE-2Z细胞膜电位负值与培养液K~+浓度对数值接近呈反比关系。而培养液Na~+、Ca~(2+)、Cl~-浓度提高时,膜电位无显著改变。提示K~+外流是形成CNE-2Z细胞膜电位的主要离子基础。
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| 关 键 词： | 鼻咽肿瘤 细胞+膜电位 离子浓度 |
THE MEMBRANE POTENTIAL AND ITS IONIC MECHANISM OF POORLY DIFFERENTIATED HUMAN NASOPHARYNGEAL CARCINOMA (CNE-2Z)CELLS |
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| Chen Lixin Wang Liwei Zeng Guanghua Nie Sihuai Guo Zhongmin Hu Xinrong Tang Weiping Zhong Ping.THE MEMBRANE POTENTIAL AND ITS IONIC MECHANISM OF POORLY DIFFERENTIATED HUMAN NASOPHARYNGEAL CARCINOMA (CNE-2Z)CELLS[J].Journal of Guangdong Medical College,1993(Z1). |
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| Authors: | Chen Lixin Wang Liwei Zeng Guanghua Nie Sihuai Guo Zhongmin Hu Xinrong Tang Weiping Zhong Ping |
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| Institution: | Chen Lixin Wang Liwei Zeng Guanghua Nie Sihuai Guo Zhongmin Hu Xinrong Tang Weiping Zhong Ping Department of Physiology; Department of PathologY |
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| Abstract: | The membrane potentials of poorly differentiated human nasopharyngeal carcinoma (CNE-2Z ) cells in culture and the forming mechanism were studied by means of intracellular recordings using glass microelectrodes. The results indicated that the negative values of membrane
potentials of CNE-2Z cells increased significantly compared with the normal nasopharyngeal
epithelial cells (P<0. 01). The coefficient of variation of membrane potentials in CNE - 2Z cells was large and the distribution was diffuse. The negative values of membrane potentials
of CNE - 2Z cells were inversely proportional to the logarithm of K+concentration in the medium (lgCK+D) .whereas the membrane potentials did not change significantly while Na+ , Ca2+ and Cl~ concentration in the medium was increased respectively. It is suggested that the outward diffusion of intracellular K+ be the main ionic basis that establishes the membrane potentials of CNE-2Z cells. |
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| Keywords: | rhinopharyngeal neoplasms cells + membrane potentials ion concentration |
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