| 双黄连口服液的急性毒性试验研究 |
| |
| 引用本文： | 张晓会.双黄连口服液的急性毒性试验研究[J].中国兽药杂志,2011,45(12):29-30. |
| |
| 作者姓名： | 张晓会 |
| |
| 作者单位： | 国家兽用药品工程技术研究中心,河南洛阳,471003 |
| |
| 摘 要： | 为了解双黄连口服液在使用过程中的安全性，参照《兽药注册资料汇编》中兽药急性毒性试验指导原则的要求，选用小白鼠进行急性毒性试验。小白鼠的最小致死量、半数致死量测定结果显示：双黄连口服液对小白鼠最小致死量范围为49．2～60．8g／b，相当于禽临床用量的111．8—138．2倍，说明双黄连口服液临床应用具有一定的安全性。
|
| 关 键 词： | 双黄连口服液 小鼠 急性毒性 |
| 收稿时间： | 7/7/2011 12:00:00 AM |
| 修稿时间： | 2011/8/25 0:00:00 |
Research of Acute Toxicity of the Shuanghuanglian Oral Liquid |
| |
| Institution: | ZHOU De - gang, ZHANG Xiao - hui, LIU Xing - jin, GAO Fu - hong ( National Research Center for Veterinary Medicine,Luoyang, Henan 471003, China) |
| |
| Abstract: | In order to observe the applied reliability of the Shuanghuanglian Oral Liquid, the experiment was conducted in accordance with acute toxicity requirements in the animal drug administration compile of Ministry Agriculture. The acute toxicity of Shuanghuanglian oral liquid was studied by selecting rat in this experiment ,the toxicity of Shuanghuanglian oral liquid was demonstrated by the minimal lethal dose and the LD50 of rats. The results showed that the minimal lethal dose ranged between 49.2 and 60.8 g/kg and the LD50 was 75.66 g/kg. |
| |
| Keywords: | Qinhuang Oral Liquid rats acute toxicity |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国兽药杂志》浏览原始摘要信息 |
| 点击此处可从《中国兽药杂志》下载免费的PDF全文 |
|
