Biovailability of ivermectin administered orally to dogs |
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| Authors: | C P Daurio E N Cheung A R Jeffcoat B J Skelly |
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| Institution: | (1) Merck Sharp and Dohme Research Laboratories, 07065 Rahway, NJ, USA;(2) Research Triangle Institute, 27709 Research Triangle Park, NC, USA |
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| Abstract: | The bioavailability of three formulations of ivermectin was determined following oral administration to dogs. The average peak plasma level (C
max) of ivermectin administered in the standard tablet formulation at 6 and 100 µg/kg of body weight was 2.97 and 44.31 ng/g, respectively. This suggest dose-dependent pharmacokinetics.C
max and total ivermectin bioavailability, as assessed from the area under the plasma curve (AUC), were similar between two tablet formulations of ivermectin administered at 100 µg/kg. Furthermore,C
max was similar following administration of radiolabelled ivermectin at 6 µg/kg in either a beef-based chewable formulation or in the standard tablet formulation. |
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| Keywords: | bioavailability dogs ivermectin oral formulations pharmacokinetics |
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