Membranous Glomerulonephropathy in a Hatano Low-avoidance Rat |
| |
| Authors: | Kyohei Yasuno Haruka Sakashita Ryosuke Kobayashi Saori Araki Rio Saito Mariko Shirota Junichi Kamiie Kinji Shitora |
| |
| Institution: | 1. Research Institute of Biosciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan;2. Laboratory of Comparative Toxicology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan;3. Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan |
| |
| Abstract: | Membranous glomerulonephropathy can be experimentally induced in rats, but spontaneous
cases have been rarely reported. In this report, we present a typical case of spontaneous
membranous glomerulonephropathy in a rat. A male Hatano low-avoidance (LAA) strain rat had
a tumor mass on the right auricle, and was sacrificed at 41 weeks of age. Urinary
screening by reagent strips revealed intense proteinuria. Histological tests revealed
frequent presence of irregularly sized eosinophilic hyaline materials on the capillary
wall and in the mesangium of renal glomeruli. Immunofluorescence revealed granular
deposits of IgG, IgM, and C3 in the glomeruli. Subepithelial dense deposits were observed
by electron microscopy accompanied by podocyte foot process effacement and occasional
irregular thickening of the glomerular basement membrane. The rat also developed chronic
lymphocytic pancreatitis, and the tumor mass on the right auricle was diagnosed as a
fibrosarcoma. Screening tests for antibodies against major infectious agents and
antinuclear antibody were negative. Western blot and indirect immunofluorescence analyses
suggested the presence of an autoantibody against the pancreatic component. The
glomerulopathy was considered an early stage of membranous glomerulonephropathy. |
| |
| Keywords: | immunopathology kidney membranous glomerulonephropathy nephrology rat |
|
|
