CD4+ and CD8+ T- lymphocytopenia in a filly with Pneumocystis carinii pneumonia |
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| Authors: | MJBF FLAMINIO BR RUSH JH COX WE MOORE |
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| Institution: | Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606, USA |
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| Abstract: | Decreased proportion of CD4+ and CD8+ T lymphocytes in peripheral blood likely contributed to susceptibility to Pneumocystis carinii in a foal. Cytological evaluation of bronchoalveolar lavage was required for identification of the pathogen and serial flow-cytometric analysis of peripheral blood lymphocytes documented transient low expression of CD4+ and CD8+ T lymphocytes. Although immunodeficiency is uncommon, it must be included in the differential diagnosis for patients suffering from chronic or opportunistic infections and may provide an indication for immunostimulant therapy. |
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| Keywords: | Immunodeficiency lymphocyte subpopulations flow cytometer Pneumocystis carinii horse |
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