Antagonism of medetomidine sedation by atipamezole in pigs. |
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| Authors: | R Nishimura H Kim S Matsunaga M Sakaguchi N Sasaki H Tamura A Takeuchi |
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| Institution: | Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan. |
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| Abstract: | The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 micrograms/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 micrograms/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 micrograms/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose. |
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