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| 吡喹酮注射液对水牛血吸虫病的临床治疗效果 | |
| 引用本文： | 杨海峰,李勇军,陆广富,陶建平.吡喹酮注射液对水牛血吸虫病的临床治疗效果[J].中国畜牧兽医,2017,44(5):1552-1556. |
| 作者姓名： | 杨海峰 李勇军 陆广富 陶建平 |
| 作者单位： | 1. 江苏农牧科技职业学院, 泰州 225300; 2. 扬州大学兽医学院, 扬州 225009; 3. 江苏倍康药业有限公司, 泰州 225300 |
| 基金项目： | 国家农业科技成果转化资金项目（2011GB2C100019）；江苏省高校青蓝工程资助项目 |
| 摘 要： | 采用粪便毛蚴孵化法筛选自然感染血吸虫病水牛，考察30%吡喹酮注射液对水牛血吸虫病的临床治疗效果。在实验性临床试验中，将自然感染血吸虫病水牛随机分为5组，分别为吡喹酮注射液高（20 mg/kg）、中（10 mg/kg）、低（5 mg/kg）剂量组，吡喹酮片组（30 mg/kg）和阳性对照组（不用药组）。给药30 d后，吡喹酮注射液高、中、低剂量组及吡喹酮片组的粪便毛蚴孵化转阴率分别为100.0%、100.0%、77.8%和85.7%。在扩大临床试验中，将自然感染血吸虫病水牛随机分为2组，分别为吡喹酮注射液推荐剂量组（10 mg/kg）和吡喹酮片组（30 mg/kg），给药30 d后，吡喹酮注射液组的52头患牛的粪便毛蚴孵化转阴率为100%，吡喹酮片组的6头患牛的粪便毛蚴孵化转阴率为100%。研究结果表明，30%吡喹酮注射液对水牛血吸虫病具有良好的治疗效果，给药方便，可以替代传统内服片剂，临床推荐剂量为10 mg/kg。 |
| 关 键 词： | 吡喹酮注射液 水牛血吸虫病 临床治疗效果 毛蚴转阴率 |
| 收稿时间： | 2016-10-10 |
Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis |
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| YANG Hai-feng,LI Yong-jun,LU Guang-fu,TAO Jian-ping.Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis[J].China Animal Husbandry & Veterinary Medicine,2017,44(5):1552-1556. | |
| Authors: | YANG Hai-feng LI Yong-jun LU Guang-fu TAO Jian-ping |
| Institution: | 1. Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, China; 2. College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China; 3. Jiangsu Beikang Pharmaceutical Company Limited, Taizhou 225300, China |
| Abstract: | To observe the clinical therapeutic effect of 30% praziquantel injection on buffalo schistosomiasis, the sick buffalos naturally infected with Schistosoma japonicum were selected by miracidium hatching method. In experimental clinical trials, sick buffalos were randomly divided into five groups, high-dose (20 mg/kg), middle-dose (10 mg/kg) and low-dose (5 mg/kg) praziquantel injection groups, praziquantel tablet group (30 mg/kg) and positive control group. After the treatment of 30 d, the negative conversion rate of miracidium were 100.0%, 100.0%, 77.8% and 85.7%, respectively, in praziquantel injection groups with the high, middle and low dose and oral medication group. In expanded clinical trials, the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg). The results showed that, the negative conversion rate of miracidium were all 100% in the former 52 patients and the latter 6 patients after 30 d. The research confirmed that praziquantel injection was significantly effective in the treatment of buffalo schistosomiasis and convenient for administration. It was concluded that 30% praziquantel injection could replace the traditional oral praziquantel tablet for the treatment of buffalo schistosomiasis, and the recommended dose was 10 mg/kg. |
| Keywords: | praziquantel injection buffalo schistosomiasis clinical therapeutic effect negative conversion rate of miracidium |
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