| N-(4,6-二取代嘧啶-2-基)苯甲酰胺类化合物的合成与杀菌活性 |
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| 引用本文： | 黄明智,罗晓艳,任叶果,张承来,张俐,徐满才.N-(4,6-二取代嘧啶-2-基)苯甲酰胺类化合物的合成与杀菌活性[J].农药学学报,2007,9(1):76-79. |
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| 作者姓名： | 黄明智 罗晓艳 任叶果 张承来 张俐 徐满才 |
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| 作者单位： | 1.湖南化工研究院 国家农药创制工程技术研究中心,长沙 410007 |
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| 摘 要： | 为了寻找高效、安全的杀菌活性化合物,设计并合成了8个N-(4,6-二取代嘧啶-2-基)苯甲酰胺类化合物,其化学结构经1H NMR、IR、LC/MS和元素分析确证。 初步生物活性测定结果表明,该类化合物具有一定的杀菌活性,当浓度为25 mg/L时,化合物 4g 对稻瘟病菌Pyricularia oryzae的抑制率达85.1％,化合物 4f 对小麦赤霉病菌Gibberella zeae的抑制率达92.9％。
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| 关 键 词： | 2-氨基嘧啶 苯甲酰胺 合成 杀菌活性 |
| 文章编号： | 24075838 |
| 收稿时间： | 2006/8/29 0:00:00 |
| 修稿时间： | 08 29 2006 12:00AM |
Synthesis and Fungicidal Activity of N-(4,6-Disubstitued pyrimidin-2-yl)-benzamides |
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| HUANG Ming-zhi,LUO Xiao-yan,REN Ye-guo,ZHANG Cheng-lai,ZHANG Li and XU Man-cai.Synthesis and Fungicidal Activity of N-(4,6-Disubstitued pyrimidin-2-yl)-benzamides[J].Chinese Journal of Pesticide Science,2007,9(1):76-79. |
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| Authors: | HUANG Ming-zhi LUO Xiao-yan REN Ye-guo ZHANG Cheng-lai ZHANG Li and XU Man-cai |
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| Institution: | 1.National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha 410007,China2.College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,China |
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| Abstract: | In search of safer and more effective fungicidal compounds,eight N-(4,6-disubstitued pyrimidin-2-yl)-benzamides were designed and synthesized.Their structures were confirmed by IR,1H NMR,LC/MS and elemental analysis.Preliminary bioassay showed that some of the title compounds showed good fungicidal activity,for example,4g exhibited 85.1% inhibition rate to Pyricularia oryzae at 25 mg/L and 4f exhibited 92.9% inhibition rate to Gibberella zeae at 25 mg/L. |
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| Keywords: | 2-aminopyrimidine benzamide synthesis fungicidal activity |
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