| 微波对雏鸡的认知功能和NMDA受体亚基基因表达的影响（摘要） |
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| 引用本文： | 邢瑞,车轶,崔勇华,徐世清.微波对雏鸡的认知功能和NMDA受体亚基基因表达的影响（摘要）[J].农业科学与技术,2011(3):389-393. |
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| 作者姓名： | 邢瑞 车轶 崔勇华 徐世清 |
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| 作者单位： | 苏州大学医学部基础医学与生物科学学院 |
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| 基金项目： | Supported by Suzhou City Science and Technology Bureau Item(YJS0904)~~ |
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| 摘 要： | 目的]研究微波对鸡胚生长发育及雏鸡认知功能的影响。方法]采用磁控管发射2450MHz的微波来模拟微波辐射源辐射种蛋,直到雏鸡孵出后,分别采用一次性被动回避学习和RT-PCR检测微波对雏鸡的认知功能和NMDA受体NR1亚基与NR2亚基表达量的影响。结果]微波辐射后暴露组的回避率显著低于对照组,特别在辐射强度最高组的回避率极显著低于对照组。同时暴露组有2组雏鸡体重增加,其中一组的孵化时间有所增加。经RT-PCR分析,NR2亚基表达量在第10天而及15天时都上调,NR1亚基表达量只在第15天时才下调。结论]微波对个体发育具有一定影响,通过使端脑中NMDA受体结构组成和功能发生改变,使自身的调节能力下降,从而对认知功能有一定损害。
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| 关 键 词： | 微波 认知功能 NMDA受体 NR1亚基 NR2亚基 |
Influences of Microwave on the Cognitive Function of Chickling and the Gene Expression of NMDA Receptor Subunit |
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| XING Rui,CHE Yi,CUI Yong-hua,XU Shi-qing.Influences of Microwave on the Cognitive Function of Chickling and the Gene Expression of NMDA Receptor Subunit[J].Agricultural Science ＆ Technology,2011(3):389-393. |
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| Authors: | XING Rui CHE Yi CUI Yong-hua XU Shi-qing |
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| Institution: | College of Basic Medicine and Biological Sciences,Suzhou University,Suzhou 215123 |
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| Abstract: | Objective] The research aimed to study the effects of microwave on the chick embryo development and the cognitive function of chickling. Method] The microwave which was transmitted by the permatron and was 2 450 MHz was used to simulate the microwave radiation source to radiate the hatching eggs until the chickling was hatched out. The disposable passive avoidance learning and RT-PCR were respectively used to detect the influences of microwave on the cognitive function of chickling and the expression amounts of NMDA receptor NR1 and NR2 subunits. Result] After the microwave radiation,the avoidance rate of exposed group was significantly lower than that in the control group. Especially the avoidance rate of highest radiation intensity group was extremely significantly lower than that in the control group. Meanwhile,the body weights of two groups of chickling in the exposed group increased,and the hatching time in one group increased. Via RT-PCR analysis,the expression amount of NR2 subunit increased on the 10th day and the 15th day. The expression amount of NR1 subunit only decreased on the 15th day. Conclusion] The microwave had the certain influence on the individual development. By changing the structure composition and function of NMDA receptor in the endbrain,the microwave made the self-regulation ability of chickling decline,which had the certain damage on the cognitive function. |
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| Keywords: | Microwave Cognitive function NMDA receptor NR1 subunit NR2 subunit |
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