| 核酸疫苗研究进展(下) |
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| 引用本文： | 江国托.核酸疫苗研究进展(下)[J].现代畜牧兽医,2005(3):40-42. |
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| 作者姓名： | 江国托 |
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| 作者单位： | 大连三仪生物工程研究所,辽宁,大连,116036 |
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| 摘 要： | Sato等报道，在质粒载体上引入大肠杆菌Amp^ 抗性基因(内含有6核苷酸片段的ISS免疫增强序列)，真皮免疫小鼠后ISS增强CTL和Th1细胞的免疫反应。有人提出利用含有病毒免疫原性基因的基因大片段进行基因免疫，以弥补单基因免疫活性的不足。将协同因子如IL-2、IL-12、TCA等的表达质粒与抗原表达质粒混合注射可使Th1型细胞免疫增强，而GMcsf能明显加强体液免疫，
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| 关 键 词： | 核酸疫苗 基因工程疫苗 安全性 免疫保护力 |
| 文章编号： | 1672-9692(2005)03-0040-03 |
| 修稿时间： | 2004年12月13 |
Research Development of Nucleic Acid Vaccine |
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| Jiang Guotuo.Research Development of Nucleic Acid Vaccine[J].Modern JOurnal of Animal Husbandry and Veterinary Medicine,2005(3):40-42. |
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| Authors: | Jiang Guotuo |
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| Abstract: | In the past 15 years, the rapid progress on the research and using of the nucleic acid vaccine has been made all over the world. In present paper, the development about the nucleic acid vaccine were summarized from the fields of genetic tretment and nucleic acid vaccine, immunization methods of nucleic acid vaccine, mechanism of immunity responding, the method to enhance the role of nucleic acid vaccine and the advantage and safety of nucleic acid vaccine, respectively . |
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| Keywords: | Nucleic acid vaccine Research development |
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