| 噻二唑基-3-哒嗪酮类化合物的合成及生物活性 |
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| 引用本文： | 曹松,曲玉成,宋恭华,钱旭红,黄青春,卢德力.噻二唑基-3-哒嗪酮类化合物的合成及生物活性[J].农药学学报,2004,6(2):68-71. |
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| 作者姓名： | 曹松 曲玉成 宋恭华 钱旭红 黄青春 卢德力 |
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| 作者单位： | 1.华东理工大学 药物化工研究所，上海市化学生物学(芳香杂环)重点实验室，上海 200237 |
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| 基金项目： | 上海市科委资助项目，上海市学科科研项目 |
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| 摘 要： | 将取代的二酰基肼环合后,得到中间体2-芳基-5-氯甲基-1,3,4-噻二唑,然后与2-叔丁基-4-氯-5-羟基-3(2H)-哒嗪酮反应,合成了8个未见文献报道的含噻二唑基哒嗪酮类化合物,其化学结构经1H NMR、高分辩质谱和元素分析确认。生物活性测试结果表明,部分化合物对粘虫P.separate W.有较好的抑制生长活性,其中化合物 3b 的EC50值为21 mg/L。
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| 关 键 词： | 噻二唑 哒嗪酮 合成 生物活性 |
| 文章编号： | 1008-7303(2004)02-0068-04 |
| 收稿时间： | 2003/12/15 0:00:00 |
| 修稿时间： | 2003年12月15 |
Synthesis and Biological Activities of New Thiadiazolyl 3-pyridazinones |
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| CAO Song,QU Yu-cheng,SONG Gong-hu,QIAN Xu-hong,HUANG Qing-chun and LU De-li.Synthesis and Biological Activities of New Thiadiazolyl 3-pyridazinones[J].Chinese Journal of Pesticide Science,2004,6(2):68-71. |
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| Authors: | CAO Song QU Yu-cheng SONG Gong-hu QIAN Xu-hong HUANG Qing-chun and LU De-li |
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| Institution: | 1.Institute of Pesticides and Pharmaceutical, East China University of Science and Technology, P.O. Box 544, 130 Meilong Road, Shanghai 200237, China |
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| Abstract: | Eight new thiadiazolyl 3(2H)-pyridazinones compounds were synthesized by the reaction of 2-tert-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinones with 5-aryl-2-chloromethyl-1,3,4-oxadiazoles which were prepared by the cyclization of N-chloroacetyl-N'-aroylhydrazines. The structure of the title compounds were confirmed by 1H NMR, HR mass spectra and elemental analysis. Their biological activities were examined and some of them exhibited good activities against Pseudaletia separate Walker. The EC50 of 3b was 21 mg/L. |
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| Keywords: | thiadiazolyl pyridazinone synthesis insecticidal activities |
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