| 血清神经元特异性烯醇酶在热性惊厥患儿中的检测及意义 |
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| 引用本文： | 曾珺,吴春能,庄良鹏.血清神经元特异性烯醇酶在热性惊厥患儿中的检测及意义[J].湛江医学院学报,2006,24(6):572-573. |
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| 作者姓名： | 曾珺 吴春能 庄良鹏 |
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| 作者单位： | 广东省徐闻县人民医院儿科 广东徐闻524100 |
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| 摘 要： | 目的:探讨热性惊厥(FC)患儿血清神经元特异性烯醇酶(N SE)变化的临床意义。方法:选择单纯性FC 37例、复杂性FC 17例和对照组患儿30例,用EL ISA法测定其血清中的NES质量浓度,并于FC发作2周后检查脑电图。结果:复杂性FC患儿血清NES质量浓度明显高于单纯性组和对照组(P均<0.01),单纯性FC组和对照组比较则差异无统计学意义(P>0.05)。脑电图异常患儿血清NES质量浓度明显高于脑电图无异常者和对照组(P均<0.01),脑电图无异常组和对照组比较差异无统计学意义(P>0.05)。惊厥发作持续时间≥15 m in FC患儿血清NES质量浓度明显高于发作持续时间<15m in者和对照组(P均<0.001),发作持续时间<15m in组和对照组比较则无明显差异。结论:复杂性FC惊厥发作可引起患儿脑损伤,这种损伤可能与发作持续时间有关。
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| 关 键 词： | 神经元特异性烯醇酶 热性惊厥 儿童 |
| 文章编号： | 1005-4057(2006)06-0572-02 |
| 收稿时间： | 09 13 2006 12:00AM |
| 修稿时间： | 10 25 2006 12:00AM |
Serum neuron specific enolase in children with febrile convulsion |
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| ZEN Jun,WU Chu-nen,ZHUANG Liang-peng.Serum neuron specific enolase in children with febrile convulsion[J].Journal of Guangdong Medical College,2006,24(6):572-573. |
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| Authors: | ZEN Jun WU Chu-nen ZHUANG Liang-peng |
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| Abstract: | Objective: To study the clinical significance of serum neuron specific enolase(NES) in children with febrile convulsion(FC).Methods: Serum levels of NES were detected by ELISA in 54 children with FC(simple FC,n=37;complex FC,n=17) and 30 controls.All patients with FC received electroencephalogram(EEG) 2 weeks after the attack of FC.Results: Serum levels of NES were higher in complex FC than those in simple FC group(P<0.001) and control group(P<0.01),especially in patients with abnormal EEG and duration of FC being 15 min or more,but there was no statistical difference in serum levels of NES between simple FC and control group(P>0.05).Conclusion: The complex FC may induce the damage of brain,which could be related to the duration of FC. |
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| Keywords: | neuron specific enolase febrile convulsion children |
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