| 低钙或(和)低蛋白饲料对大鼠腰椎的骨计量学研究 |
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| 引用本文： | 黄连芳,李青南,廖进民,陈艳,冷扬.低钙或(和)低蛋白饲料对大鼠腰椎的骨计量学研究[J].湛江医学院学报,2004,22(6):557-559. |
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| 作者姓名： | 黄连芳 李青南 廖进民 陈艳 冷扬 |
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| 作者单位： | 广东医学院骨生物学研究室 广东湛江524023
(黄连芳，李青南，廖进民，陈艳)，广东医学院骨生物学研究室 广东湛江524023(冷扬) |
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| 基金项目： | 广东省科委重点科技攻关项目 (No 99B0 780 1Q ) |
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| 摘 要： | 目的 :观察并比较低钙、低蛋白饲料和混合低钙低蛋白饲料对大鼠腰椎松质骨的影响。方法 :2 7只 3月龄 SD雄性大鼠 ,随机分成正常对照组、低钙组 (Ca0 .0 1% )、低蛋白组 (Pr8% )和混合组 (Ca0 .0 1% + Pr8% )。实验 90 d时取第 5腰椎行不脱钙骨制片 ,骨组织形态计量学测量。结果 :与对照组比 ,低钙组骨小梁面积百分率 (% Tb.Ar)减少 (P<0 .0 5 ) ,骨吸收增加 ;低蛋白组骨量 (% Tb.Ar)经统计学处理后差异尚未达到显著性 ;混合组骨量比对照组、低蛋白组显著降低 ,骨吸收及骨转换率明显增加。结论 :低钙饲料使大鼠腰椎的骨吸收增加 ,骨量减少 ,出现骨质疏松 ;低蛋白饲料对大鼠腰椎骨丢失无明显影响 ;但混合低钙低蛋白饲料则使骨吸收增加、骨形成率增高 ,导致骨转换增强 ,骨量进一步降低。
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| 关 键 词： | 饮食 钙 骨质疏松 骨组织形态计量学 |
| 文章编号： | 1005-4057(2004)06-0557-03 |
| 修稿时间： | 2004年2月23日 |
Effect of low calcium or (and) protein diet on lumbar vertebra of rats by bone histomorphometry |
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| HUANG Lian-fang,LI Qing-nan,LIAO Jin-ming,CHEN Yan,LENG Yang.Effect of low calcium or (and) protein diet on lumbar vertebra of rats by bone histomorphometry[J].Journal of Guangdong Medical College,2004,22(6):557-559. |
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| Authors: | HUANG Lian-fang LI Qing-nan LIAO Jin-ming CHEN Yan LENG Yang |
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| Abstract: | Objective: To study the effect of low calcium and protein diet on lumbar vertebra of rats. Methods: Twenty-seven 3-month-old Sprague-Dawley male rats were randomly divided into four groups: control group, low calcium diet (LCD) group, low protein diet (LPD) group and LCD+LPD group. After 90 days, all rats were killed and L5 was harvested for bone histomorphometry. Results: Compared with the control group, bone trabecula area decreased and bone resorption increased in LCD group(P<0.05) other than in LPD group. The decrease of bone mass and the increase of bone resorption and turnover rate were significantly higher in LCD+LPD group than those in control and LPD groups (P<0.01-0.05). Conclusion: Trabecular bone loss of rats can be induced by low calcium diet, especially by low calcium and protein diet. |
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| Keywords: | diet calcium osteoporosis bone histomorphometry |
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