| 鸡马立克氏病活疫苗免疫效力比较试验 |
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| 引用本文： | 吴长新,刘秀梵.鸡马立克氏病活疫苗免疫效力比较试验[J].中国兽医学报,1996,16(5):433-438. |
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| 作者姓名： | 吴长新 刘秀梵 |
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| 作者单位： | 扬州大学农学院动物医学系 |
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| 基金项目： | 农业部“七五”重点攻关项目 江苏省“八五”重点项目 |
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| 摘 要： | 用ＨＶＴ冻干苗、ＨＶＴ细胞结合苗、ＣＶＩ９８８细胞结合苗、ＳＢ１＋ＦＣ１２６双价活疫苗、３０１Ｂ／１＋ＦＣ１２６双价活疫苗和Ｚ４＋ＦＣ１２６双价活疫苗等６种鸡马立克氏病（ＭＤ）疫苗免疫ＳＰＦ白来航鸡或普通伊莎鸡，用鸡马立克氏病病毒（ＭＤＶ）强毒ＧＡ株、京－１血毒以及鸡马立克氏病超强毒ｖｖＭＤＶ－Ｍｄ５毒株分别攻击进行免疫效力比较试验。试验表明，ＭＤ单价苗的免疫效力强弱顺序依次是ＣＶＩ９８８、ＨＶＴ细胞结合苗和ＨＶＴ冻干苗，这３种ＭＤ单价苗均能给免疫鸡群提供有效的免疫保护力。ＳＢ１＋ＦＣ１２６、Ｚ４＋ＦＣ１２６和３０１Ｂ／１＋ＦＣ１２６等３种ＭＤ双价苗免疫效力显著高于ＭＤ单价苗，均能给免疫鸡群提供较强的免疫保护力，并能有效地抵抗ｖｖＭＤＶ－Ｍｄ５毒株的致瘤作用。Ｚ４＋ＦＣ１２６和３０１Ｂ／１＋ＦＣ１２６ＭＤ双价苗免疫效力无显著差异
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| 关 键 词： | 鸡马立克氏病 单价疫苗 双价疫苗 免疫效力 比较试验 |
Comparative Protection Efficacies of Some Different Live Marek's Disease Vaccines |
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| Wu Changxin Liu Xiufan Zhang Rukuan Wu Yantao Gan Junji,Peng Daxin.Comparative Protection Efficacies of Some Different Live Marek''s Disease Vaccines[J].Chinese Journal of Veterinary Science,1996,16(5):433-438. |
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| Authors: | Wu Changxin Liu Xiufan Zhang Rukuan Wu Yantao Gan Junji Peng Daxin |
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| Abstract: | Comparative protection efficacy trials were made with 4 kinds of Marek's disease monovalent vaccines, i.e. native manufactured and imported cell free HVT lyophilized vaccines, cell associated Fc126 vaccine and CVI988 vaccine and 3 kinds of bivalent vaccines including SB1 FC126, Z4 FC126 and 301B/1 FC126 vaccines for protecting the White Leghorn SPF chickens and the comercial Isal Brown chickens from challenges of MDV GA strain, Bj 1 strain viral blood or very virulent MDV (vvMDV) MD5 strain. The results showed that the bivalent vaccines could give the immunized chickens more potent immunities against challenges of vvMDV Md5 strain or Bj 1 strain viral blood than the monovalent vaccines-cell free HVT vaccines, cell associated HVT vaccine and CVI988 vaccine could do so. Besides, the former ones were also found to be effective to protect the immunized chickens from the oncogenesis of vvMDV MD5 strain. There were no significant differences between Z4 FC126 and 301B/1 FC126 bivalent vaccines. |
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| Keywords: | Marek's disease monovalent vaccine bivalent vaccine immunity efficacy comparative trial |
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