New mosquito larvicidal tetranortriterpenoids from Turraea wakefieldii and Turraea floribunda |
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| Authors: | Ndung'u Mary W Kaoneka Bakari Hassanali Ahmed Lwande Wilber Hooper Antony M Tayman Francis Zerbe Oliver Torto Baldwyn |
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| Institution: | International Centre of Insect Physiology and Ecology, P.O. Box 30772, Nairobi, Kenya. |
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| Abstract: | The crude methanol extracts of the root barks of Turraea wakefieldii and Turraea floribunda were found to show mosquito larvicidal activity against third-instar larvae of Anopheles gambiae sensu stricto. Four new limonoids comprising a vilasininoid 1 and three havanensinoids 2-4 were isolated from the chloroform fractions of the methanol extracts of T. wakefieldii and T. floribunda, respectively. The structures of the compounds were elucidated by NMR spectroscopy. Compounds 1, 2, and 4 had LD50 values of 7.1, 4.0, and 3.6 ppm, respectively, and were more potent than azadirachtin, which had an LD50 value of 57.1 ppm when tested against larvae of A. gambiae. |
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