| 基因驱动技术研究进展及风险管控 |
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| 引用本文： | 王盼娣,熊小娟,付萍,吴刚,刘芳.基因驱动技术研究进展及风险管控[J].中国油料作物学报,2021,43(1):56-63. |
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| 作者姓名： | 王盼娣 熊小娟 付萍 吴刚 刘芳 |
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| 作者单位： | 中国农业科学院油料作物研究所，农业农村部油料作物生物学与遗传育种重点实验室；
农业农村部转基因植物环境安全监督检验测试中心（武汉），湖北武汉，430062 |
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| 基金项目： | 转基因生物新品种培育重大专项(SQ2019ZD080018)。 |
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| 摘 要： | 基因驱动是指特定基因有偏向性地遗传给下一代的自然现象,近年来成为生物学研究热点,用来防治害虫、控制传染病、清除物种入侵等.实验室已经证实,基于CRISPR/Cas9基因编辑系统的基因驱动技术可提高特定基因的遗传率.虽然基因驱动技术有非常多的潜在益处,但在伦理和社会安全方面也面临巨大挑战.本文综述了基因驱动的原理及类型,...
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| 关 键 词： | 基因驱动 超孟德尔遗传 CRISPR/Cas9基因编辑系统 应用 风险管控 |
Research advances and risk management of gene drives |
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| WANG Pan-di,XIONG Xiao-juan,FU Ping,WU Gang,LIU Fang.Research advances and risk management of gene drives[J].Chinese Journal of Oil Crop Sciences,2021,43(1):56-63. |
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| Authors: | WANG Pan-di XIONG Xiao-juan FU Ping WU Gang LIU Fang |
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| Institution: | Key Laboratory of Biology and Genetics Improvement of Oil Crops, Supervision and Test Center (Wuhan) for Environ⁃
mental Safety of Genetically Modified Plants，Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute,
Chinese Academy of Agricultural Sciences, Wuhan 430062, China |
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| Abstract: | Gene drives,a natural phenomenon,means a specific gene can be biased to next generation.This phenomenon has recently become one of the new research hotspots in field of biology.It could be used to control pests and infectious diseases,and also to clear away invasive species and so on.It was verified in laboratory that gene drives based on CRISPR/Cas9 system has been successfully enhanced the heritability of specific genes.Although gene drives has many potential benefits,it faces great challenges in terms of ethics and social security.This paper reviewed the principle of gene drives,research progress and applications in recent years,and the technical problems faced by this technology including risks and governance of gene drives. |
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| Keywords: | gene drives super-Mendelian inheritance CRISPR/Cas9 gene editing application risk governance |
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