| 低温等离子体调控细胞增殖和凋亡的研究进展及其在畜牧业的应用 |
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| 引用本文： | 李雅琦,王鲜忠,张姣姣.低温等离子体调控细胞增殖和凋亡的研究进展及其在畜牧业的应用[J].畜牧兽医学报,2022,53(1):1-10. |
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| 作者姓名： | 李雅琦 王鲜忠 张姣姣 |
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| 作者单位： | 西南大学动物医学院, 重庆 400715 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(31902338);重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0056)。 |
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| 摘 要： | 低温等离子体(non-thermal plasma,NTP)是轻度电离的等离子体,其离子和中性粒子温度远低于电子温度,使得整个放电体系呈现低温状态,目前广泛应用于灭菌消毒、疫苗生产、口腔治疗、伤口愈合和癌症治疗等生物医学领域.NTP产生的活性氧(reactive oxygen species,ROS)及活性氮(reac...
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| 关 键 词： | 低温等离子体 细胞增殖 细胞凋亡 伤口愈合 癌症治疗 畜牧应用 |
| 收稿时间： | 2021-07-14 |
Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry |
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| LI Yaqi,WANG Xianzhong,ZHANG Jiaojiao.Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry[J].Acta Veterinaria et Zootechnica Sinica,2022,53(1):1-10. |
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| Authors: | LI Yaqi WANG Xianzhong ZHANG Jiaojiao |
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| Institution: | College of Veterinary Medicine, Southwest University, Chongqing 400715, China |
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| Abstract: | Non-thermal plasma(NTP)is the slightly ionized plasma.The temperature of its ions and neutral particles is far lower than that of electrons,making the whole discharge system in a low temperature state.At present,NTP is widely used in the sterilization,vaccine production,oral treatment,wound healing,cancer treatment and other biomedical fields.Reactive oxygen species(ROS)and reactive nitrogen species(RNS)produced by NTP have dose-dependent regulatrory effects on the cell proliferation and apoptosis.NTP treatments at a low intensity and short time can generate low levels of ROS and RNS,which will induce the cell proliferation and angiogenesis and thus to accelerate the wound healing.NTP treatments at a high intensity and long time can inhibit the cell proliferation and even induce the cell apoptosis.However,the mechanism of NTP regulating the cell proliferation and apoptosis and its potential application in the animal husbandry are still unclear.Therefore,this paper reviews the effects and possible mechanisms of NTP on endothelial cells,keratinocytes,fibroblasts,stem cells and malignant tumor cells,so as to provide a theoretical basis for the application of NTP in the wound healing and cancer treatment.This paper also summarizes the potential applications of NTP in the breeding environment and health,the growth and reproductive performance of livestock and poultry,as well as the animal food processing and preservation,so as to lay a foundation for promoting the animal husbandry production and ensuring the animal food safety in China. |
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| Keywords: | non-thermal plasma cell proliferation cell apoptosis wound healing cancer treatment animal husbandry application |
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