| ADP-核糖基化调控精子形成的研究进展 |
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| 引用本文： | 段晨莹,李欣,赵俊金,李茹意,赵羚均,郭冠华,杨利国,滑国华,王栋.ADP-核糖基化调控精子形成的研究进展[J].畜牧兽医学报,2022,53(1):11-19. |
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| 作者姓名： | 段晨莹 李欣 赵俊金 李茹意 赵羚均 郭冠华 杨利国 滑国华 王栋 |
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| 作者单位： | 1. 中国农业科学院北京畜牧兽医研究所, 北京 100193;2. 吉林农业大学动物科学技术学院, 长春 130118;3. 全国畜牧总站, 北京 100125;4. 山西农业大学动物科学学院, 太谷 030801;5. 华中农业大学农业动物遗传育种与繁殖教育部重点实验室, 武汉 430070 |
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| 基金项目： | 国家自然科学基金(31772595)。 |
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| 摘 要： | ADP-核糖基化是由ADP-核糖基转移酶((ADP-ribosyl) transferases,ARTs)催化的一种蛋白质翻译后修饰,分为聚-ADP-核糖基化和单-ADP-核糖基化,在着丝点和纺锤体组装、DNA损伤修复及精子染色质重塑等多个精子发生生物学事件中发挥重要调控作用.部分ARTs基因缺失使精子形成异常,导致精...
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| 关 键 词： | ADP-核糖基化 精子形成 聚-ADP-核糖基聚合酶 ecto-ADP-核糖基转移酶 |
| 收稿时间： | 2021-03-24 |
Research Progress of ADP-ribosylation in Regulating Spermatogenesis |
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| DUAN Chenying,LI Xin,ZHAO Junjin,LI Ruyi,ZHAO Lingjun,GUO Guanhua,YANG Liguo,HUA Guohua,WANG Dong.Research Progress of ADP-ribosylation in Regulating Spermatogenesis[J].Acta Veterinaria et Zootechnica Sinica,2022,53(1):11-19. |
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| Authors: | DUAN Chenying LI Xin ZHAO Junjin LI Ruyi ZHAO Lingjun GUO Guanhua YANG Liguo HUA Guohua WANG Dong |
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| Institution: | 1. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;2. College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China;3. National Animal Husbandry Service, Beijing 100125, China;4. College of Animal Science, Shanxi Agricultural University, Taigu 030801, China;5. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction(Huazhong Agricultural University), Ministry of Education, Wuhan 430070, China |
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| Abstract: | ADP-ribosylation is a kind of post-translational modification of proteins catalyzed by ADP-ribosyl transferases(ARTs).It is divided into poly-ADP-ribosylation and mono-ADP-ribosylation,which plays an important role in regulating many biological events during spermatogenesis,such as assembly of centromere and spindle,DNA damage repair and chromatin condensation.Part of the ARTs gene deletion leads to abnormal spermatogenesis,resulting in reduced semen quality and even male infertility.However,the detailed mechanism of spermatogenesis regulated by ADP-ribosylation is still unclear,and the understand on the role of mono-ADP-ribosylation within it is even less.Therefore,this paper reviews the research progress of ADP-ribosylation in spermatogenesis,hoping to provide new ideas for further revealing the regulatory mechanism of spermatogenesis,and promoting breakthrough in the prevention and control of male reproductive disorders and the treatment of male infertility. |
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| Keywords: | ADP-ribosylation spermatogenesis poly-ADP-ribose polymerases ecto-ADP-ribosyl transferase |
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