| Lewis酸催化加氢合成天然茴香基丙酮及工艺优化 |
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| 引用本文： | 王勇,吴光耀,马莉,朱凯.Lewis酸催化加氢合成天然茴香基丙酮及工艺优化[J].林产化学与工业,2016(3):121-126. |
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| 作者姓名： | 王勇 吴光耀 马莉 朱凯 |
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| 作者单位： | 南京林业大学化学工程学院 江苏省生物质绿色燃料与化学品重点实验室,江苏 南京,210037 |
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| 基金项目： | 江苏省高校优势学科建设工程资助项目 |
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| 摘 要： | 以天然亚茴香基丙酮为原料,Lewis酸为催化剂,环己烷为氢源,研究了天然茴香基丙酮的合成工艺,并探讨反应机理和反应的选择性。对不同Lewis酸催化剂与溶剂进行筛选,确定Al Cl3为催化剂,CH2Cl2为溶剂,采用正交试验方法对茴香基丙酮合成工艺进行优化,得到最佳工艺条件。在反应温度35℃,反应时间4 h,n(Al Cl3)∶n(亚茴香基丙酮)4∶1,n(环己烷)∶n(亚茴香基丙酮)4∶1的条件下反应稳定性较好,产物得率达95.1%。采用IR、GC-MS和1H NMR等分析技术对合成所得产物进行了表征。
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| 关 键 词： | 茴香基丙酮 亚茴香基丙酮 AlCl3 加氢 |
Synthesis and Process Optimization of Hydrogenation of Natural Anisyl Acetone Using Lewis Acid as Catalysts |
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| Abstract: | Synthesis of natural anisyl acetone was investigated by using natural base to Asia anisyl acetone as raw material , Lewis acid as catalyst , cyclohexane as a source of hydrogen .Different Lewis acid catalysts with different solvents were screened .The optimum synthesis conditions were determined based on the orthogonal test results as follows :the reaction temperature is 35 ℃, n(AlCl3)∶n(asia anisyl acetone)4∶1 and n(cyclohexane)∶n(asia anisyl acetone)4∶1.Three experiments were carried out under these conditions .A good stability was obtained .The yield of the product 4-( 4-methoxyphenyl )-2-butanone could reach 95%.Reaction mechanism and selective of product were discussed .The structure of the product was identified by FT-IR, GC-MS and 1H NMR spectrum. |
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| Keywords: | anisyl acetone 4-(4-methoxyphenyl )-2-butanone AlCl3 hydrogenation |
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