| 新一代烟碱类杀虫剂呋虫胺及中间体合成新工艺的研究 |
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| 引用本文： | 李杜,赵炎,李红云,王玉军,黄志华.新一代烟碱类杀虫剂呋虫胺及中间体合成新工艺的研究[J].农药科学与管理,2012,33(9):12-14. |
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| 作者姓名： | 李杜 赵炎 李红云 王玉军 黄志华 |
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| 作者单位： | 1. 山东美岁福农化有限公司,山东滨州,256200
2. 清华大学化学系,北京,100084 |
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| 摘 要： | 本文以丙二酸二乙酯为原料,在乙醇钠条件下与氯乙酸乙酯反应生成乙烷-1,2,2-三羧酸乙酯,再用硼氢化钠还原得2-羟基-1,4-丁二醇,在对甲苯磺酸的催化下脱水环合成3-羟甲基四氢呋喃,再与对甲苯磺酰氯、三乙胺反应生成3-四氢呋喃甲基对甲苯磺酸酯;甲醛水溶液、甲基硝基胍、甲胺水溶液在乙醇中反应生成1,5-二甲基-2-硝基亚胺六氢-1,3,5-三嗪;3-四氢呋喃甲基对甲苯磺酸酯与1,5-二甲基-2-硝基亚胺六氢-1,3,5-三嗪反应生成呋虫胺。
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| 关 键 词： | 呋虫胺 工艺 烟碱 新工艺 收率 |
A New Generation of Neonicotinoid Insecticide Dinotefuran and Intermediates for The Synthesis of New Technology Research |
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| Li Du,Li Hongyun,Wang YuJunShandong agriculture chemical Co.,Ltd.,MeiLuoFu,Zouping,Binzhou,Shandong,China Zhao Yan,Huang ZhiHua.A New Generation of Neonicotinoid Insecticide Dinotefuran and Intermediates for The Synthesis of New Technology Research[J].Pesticide Science and Administration,2012,33(9):12-14. |
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| Authors: | Li Du Li Hongyun Wang YuJunShandong agriculture chemical Co Ltd MeiLuoFu Zouping Binzhou Shandong China Zhao Yan Huang ZhiHua |
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| Institution: | Li Du, Li Hongyun, Wang YuJun (Shandong agriculture chemical Co., Ltd., MeiLuoFu, Zouping, Binzhou, Shandong 256200, China )Zhao Yon, Huong ZhiHua (Department of Chemistry, Tsinghua University, Beijing 100084, China) |
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| Abstract: | In this paper diethyl malonate as raw material, In the condition of ethanol sodium with reaction of ethyl chloride and produce ethane-l,2,2-three carboxylic acid ethyl ester. And then with sodium horohydride reduction produce 2-hydroxy-1,4-butanediol, In the condition of para-toluenesulfonic acid, dehydration cyclization and get methyl THF, then with paratoluen- sulfonyl chloride 、 triethylamine and produce 3-THF to methyl p-toluene sulfonic acid ester; formalin, nitroguanidine, methylamine water solution react in ethanolan and generate 1,5- dimethyl-2-nitro imine hexahydro-l,3,5-triazine; 3-THF to methyl p-toluene sulfonic acid ester react with 1,5-dimethyl-2-nitro imine hexahydro-1,3,5-triazine, produce dinotefuran. |
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| Keywords: | dinotefuran technics nicotine new process |
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