| 黑骨藤对PC12细胞氧化损伤的保护研究 |
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| 引用本文： | 张贵源,龚莉莉,余跃生,王恒,陆玉炯,杨再昌.黑骨藤对PC12细胞氧化损伤的保护研究[J].宁夏农林科技,2012,53(8):139-140. |
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| 作者姓名： | 张贵源 龚莉莉 余跃生 王恒 陆玉炯 杨再昌 |
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| 作者单位： | 1. 黔南民族医学高等专科学校,贵州都匀,558000
2. 贵州大学,贵州贵阳,550003 |
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| 基金项目： | 贵州省教育厅自然科学类一般项目 |
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| 摘 要： | 目的]研究黑骨藤提取物对H2O2诱导的PC12氧化损伤的保护作用。方法]使用H2O2氧化压力诱导PC12出现氧化损伤,检测黑骨藤乙醇提取物对PC12细胞的保护作用。结果]与模型对照组相比,黑骨藤乙醇提取物浓度在16~128μg/mL时,能显著提高PC12细胞的存活率,呈典型的量效关系。结论]黑骨藤乙醇提取物具有抗氧化损伤作用。
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| 关 键 词： | 黑骨藤 PC12细胞 抗氧化 |
Protective Effects of Periploca forrestii Schltr. Root Extract Against Cytotoxicity Induced by Hydrogen Peroxide in PC12 Cells |
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| Institution: | ZHANG Gui-yuan et al.(Southern Guizhou National Medical College,Douyun,Guizhou 558000) |
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| Abstract: | Objective] The aim was to study the protective effects of Periploca forrestii Schltr.root extract against cytotoxicity induced by hydrogen peroxide in PC12 cells.Method] The model of PC12 cells toxicity induced by hydrogen peroxide was established and the protective effects of Periploca forrestii Schltr.root extract on PC12 cells were detected.Result] Compared to negative control,Periploca forrestii Schltr.root extract could protect PC12 cells at concentration ranges of 16-128 ug/mL at a dose-response manner.Conclusion] Periploca forrestii Schltr.root extract showed anti-oxidative effect on PC12 cells. |
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| Keywords: | Periploca forrestii Schltr PC12 cells Anti-oxidative effect |
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