Evaluation of new direct dyes for mutagenicity using the salmonella mammalian mutagenicity assay |
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| Authors: | Jin-Seok Bae Harold S Freeman |
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| Institution: | (1) Korea Dyeing Technology Center, 703-834 Daegu, Korea;(2) Department of Textile Engineering, Chemistry, and Science, North Carolina State University, 27695-8301 Raleigh, NC, USA |
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| Abstract: | A series of new direct dyes based on benzidine congeners, 2,2′-dimethyl-5,5′-dipropoxybenzidine and 5,5′-dipropoxybenzidine,
were evaluated for mutagenicity in Salmonella typhimurium strains TA98 and TA100. All of the dyes examined were judged to
be non-mutagenic with and without metabolic activation while toxicity was seen in some dyes at high doses. The study also
suggested that the standard Salmonella mutagenicity plate-incorporated assay was an excellent method for evaluation of direct
dyes for mutagenicity. |
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| Keywords: | Direct dyes Mutagenicity Salmonella Benzidine Genotoxicity Azo dyes |
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