| 禽抗菌肽—禽β-防御素的研究进展 |
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| 引用本文： | 刘胜旺.禽抗菌肽—禽β-防御素的研究进展[J].农业生物技术学报,2007,15(2). |
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| 作者姓名： | 刘胜旺 |
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| 作者单位： | 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室 |
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| 摘 要： | 抗菌肽为一类小分子的，含氨基酸残基少于100个的，具有广谱抗菌活性的多肽。禽抗菌肽属β-防御素，为防御素的一个亚类。目前，已从鸡、火鸡和驼鸟的血液、鸡与火鸡的上皮细胞、以及企鹅的胃内容物中分离到多种禽β-防御素。这类抗菌肽具有广谱抗菌活性，能抗包括革兰氏阳性菌、革兰氏阴性菌、真菌及囊膜病毒在内的许多病原微生物。本文主要综述了该类抗菌肽的分子特征、抗菌机理与应用前景，以期对进一步开展相关研究提供参考。
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| 关 键 词： | 抗菌肽 β-防御素 禽β-防御素 |
| 收稿时间： | 2006-8-14 |
| 修稿时间： | 2006-11-22 |
Avian Antimicrobial Peptides—Progress in Studying the Avian β-defensins |
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| Abstract: | Antimicrobial peptides are relatively small molecules, less than 100 amino acids, which have a broad spectrum of antimicrobial activity. Avian antimicrobial peptides, classed as β-defensins has been identified from bloods of chicken, turkey, and ostrich; epithelial cells of chicken and turkey; and king penguin stomach contents. These peptides are active against a wide range of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and enveloped virus. The present paper describes molecules characteristic, antimicrobial activity, and potential application of these peptides, to provide a suggestion for research on this topic in the future. |
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