In recent years, the resistant bacteria increased dramatically due to the abuse of antibiotics. The researches on new antibiotics faced many problems, such as prolonged development process, high cost, resistance of the bacteria appeared quickly after antibiotics coming into markets and so on, which have seriously limited the application of antibiotics in the treatment of the bacterial diseases. As a kind of natural antiseptic, phages play an important role in the bacteriolysis to the bacteria from human, animal, food or environment. This paper was reviewed on the issue of phage therapy of colibacillosis.