| 高效液相色谱—串联质谱法测定羊肉中6种磺胺类药物残留 |
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| 引用本文： | 倪永付,朱涛,闫秋成,王勇,朱莉萍.高效液相色谱—串联质谱法测定羊肉中6种磺胺类药物残留[J].农产品加工．学刊,2011(8):90-92. |
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| 作者姓名： | 倪永付 朱涛 闫秋成 王勇 朱莉萍 |
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| 作者单位： | 济宁出入境检验检疫局技术中心,山东济宁,272000 |
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| 摘 要： | 建立了高效液相色谱—串联质谱法(LC/MS/MS)测定羊肉中残留的6种磺胺类药物:磺胺喹噁啉(sulfaquinoxaline,SQX)、磺胺嘧啶(sulfadiazine,SDZ)、磺胺二甲氧嘧啶(sulfadimethoxine,SDM)、磺胺间甲氧嘧啶(sulfamonomethoxin,SMM)、磺胺对甲氧嘧啶(sulfameter,SMT)、磺胺甲噁唑(sulfamethoxazole,SMZ)。样品经乙腈匀浆提取,正己烷脱脂后旋转蒸发至近干,氮气吹干,流动相溶解并定容,再用正己烷净化后上机检测,在多反应监测模式下检测,外标法定量。结果表明,6种磺胺质量浓度在10～500μg/L内线性关系良好,相关系数R2为0.998 1～0.999 8,回收率为78%～105%,定量限为10μg/kg。
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| 关 键 词： | 磺胺类药物 残留 液相色谱—串联质谱 羊肉 |
Determination of Sulphonamides Residues in Mutton by High Performance Liquid Chromatography-tandem Mass Spectrometer |
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| Ni Yongfu,Zhu Tao,Yah Qiucheng,Wang Yong,Zhu Liping.Determination of Sulphonamides Residues in Mutton by High Performance Liquid Chromatography-tandem Mass Spectrometer[J].Nongchanpin Jlagong.Xuekan,2011(8):90-92. |
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| Authors: | Ni Yongfu Zhu Tao Yah Qiucheng Wang Yong Zhu Liping |
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| Institution: | Ni Yongfu,Zhu Tao,Yan Qiucheng,Wang Yong,Zhu Liping(Ji'ning Entry-exit Inspection and Quarantine Bureau,Ji'ning,Shandong 272000,China) |
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| Abstract: | A method for the determination of six sulphonamides(sulfaquinoxaline,sulfadiazine,sulfadimethoxine,sulfamonomethoxin,sulfameter,sulfamethoxazole) residues in mutton tissue is established.The sample is extracted by acetonitrile and detected by High Performance Liquid Chromatography-tandem mass spectrometer.The results show that the correlation coefficients of linear calibration curves R2=0.998 1～0.999 8 within the sulphonamides concentration range of 10～500 μg/L,the detection limits of this method are 10μg/kg and the recovery rates are 78%～105%. |
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| Keywords: | sulphonamides residue analysis liquid chromatography-tandem mass spectrometer mutton tissue |
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