| 丙型肝炎感染者IL-2、IL-6、IL-18血清水平的研究 |
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| 引用本文： | 陈小芳,王翠霞.丙型肝炎感染者IL-2、IL-6、IL-18血清水平的研究[J].湛江医学院学报,2006,24(6):579-580. |
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| 作者姓名： | 陈小芳 王翠霞 |
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| 作者单位： | 广东医学院医学检验实验室 广东湛江524023 |
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| 摘 要： | 目的:探讨血清IL-2、IL-6、IL-18水平与丙型肝炎病变的关系。方法:运用EL ISA法检测不同类型丙型肝炎感染者血清3种细胞因子IL-2、IL-6、IL-18的水平,观察感染者细胞因子水平与肝炎发展的关系。结果:慢性及重症肝炎感染者血清IL-2水平出现显著性下调(P<0.05),而慢性及重症肝炎感染者的IL-6、IL-18的水平均显著高于正常对照组(P<0.05或P<0.01),升高程度与病情相关。结论:血中细胞因子水平是判断丙肝感染者免疫状态及进行治疗的重要指标。
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| 关 键 词： | 丙型肝炎 IL-2 IL-6 IL-18 免疫损伤 |
| 文章编号： | 1005-4057(2006)06-0579-02 |
| 收稿时间： | 06 13 2006 12:00AM |
| 修稿时间： | 09 20 2006 12:00AM |
Serum levels of IL-2, IL-6, IL-18 in patients with hepatitis C |
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| CHEN Xiao-fang,WANG Cui-xia.Serum levels of IL-2, IL-6, IL-18 in patients with hepatitis C[J].Journal of Guangdong Medical College,2006,24(6):579-580. |
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| Authors: | CHEN Xiao-fang WANG Cui-xia |
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| Institution: | Department of Laboratory Medicine, Guangdong Medical College, Zhanjiang 524023, China |
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| Abstract: | Objective: To investigate the relationship between serum levels of IL-2,IL-6,IL-18 and immune state of hepatitis C.Methods: Serum levels of IL-2,IL-6,IL-18 were measured in 43 patients with hepatitis C and 32 normal controls by ELISA.Results: Compared with normal controls,IL-2 contents decreased,and IL-6 and IL-18 levels increased in patients with chronic and serious hepatitis C(P<0.01 or 0.05).Conclusion: IL-2,IL-6,IL-18 are markers of the immune state of hepatitis C and are helpful in hepatitis C treatment guidance. |
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| Keywords: | hepatitis C IL-2 IL-6 IL-18 immune injury |
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