| 临床常用几种抗菌药物对HPS抗菌活性研究 |
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| 引用本文： | 邵莉萍,张继瑜,马志永.临床常用几种抗菌药物对HPS抗菌活性研究[J].安徽农业科学,2017,45(33). |
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| 作者姓名： | 邵莉萍 张继瑜 马志永 |
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| 作者单位： | 中国农业科学院兰州畜牧与兽药研究所,甘肃兰州,730050;上海兽医研究所,上海,200241 |
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| 基金项目： | "十二五"国家科技支撑计划项目，国家现代农业产业技术体系专项 |
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| 摘 要： | 目的]研究抗菌药物恩诺沙星、环丙沙星、加替沙星对27株副猪嗜血杆菌临床分离株体外抗菌活性,从而观察副猪嗜血杆菌对喹诺酮类抗菌药物的敏感性。方法]采用微量肉汤稀释法测定MIC,参考标准为美国临床和实验室标准协会(CLSI)。结果]恩诺沙星(MIC50,MIC90,0.25μg/mL,2μg/mL)、环丙沙星(MIC50,MIC90,0.125μg/mL,2μg/mL)、加替沙星(MIC50,MIC90,0.125μg/mL,1μg/mL)均表现出一定的抑菌活性,且加替沙星的抑菌活性最明显。在耐药性方面,副猪嗜血杆菌对恩诺沙星的耐药性最强(22.2%),环丙沙星(3.8%)和加替沙星(7.4%)具有轻微的耐药性。结论]抗菌药物恩诺沙星、加替沙星以及环丙沙星对副猪嗜血杆菌临床分离株具有一定的抗菌活性,在耐药性方面,HPS已经对恩诺沙星表现出一定的耐药性,因此,今后在临床上遇到副猪嗜血杆菌引起的相关疾病,可以采用合理的给药方案进行疾病的治疗,对于预防耐药菌株产生至关重要。
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| 关 键 词： | 恩诺沙星 加替沙星 环丙沙星 副猪嗜血杆菌 MIC |
Research of Antibacterial Activity of Clinical Commonly Used Drugs against HPS |
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| SHAO Li-ping,ZHANG Ji-yu,MA Zhi-yong.Research of Antibacterial Activity of Clinical Commonly Used Drugs against HPS[J].Journal of Anhui Agricultural Sciences,2017,45(33). |
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| Authors: | SHAO Li-ping ZHANG Ji-yu MA Zhi-yong |
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| Abstract: | Objective ]The purpose of the research is to evaluate the activity of the enrofloxacin,ciprofloxacin,gatifloxacin against heamophilus parasuis(27 isolates) , and we can estimate the ability of the quinolone compounds and oxazolidinone antibacterial against heamophilus parasuis (HPS).Method] Broth microdilution method was used to determine MIC, following the Clinical and Laboratory Standards Institute (CLSI) rec-ommendations.Result] Enrofloxacin(MIC50,MIC90,0.25ug/mL,2ug/mL),ciprofloxacin(MIC50,MIC90,0.125ug/mL,2ug/mL) , gatifloxacin (MIC50,MIC90,0.125ug/mL,1ug/mL)exhibited activity against HPS,gatifloxacin was the best one of compounds in aspect of inhibition HPS.In repect of resistance , HPS was most resistant for enrofloxacin(22.2%), and showed a little resistance for ciprofloxacin(3.8%) and gatifloxacin (7.4%) .Conclusion] The compounds of quinolone revealed better antibacterial activity than the oxazolidinone antibacterial-linezolid, and linezolid dosen' t show the function to restrain HPS.As respect of resistance , HPS reveals severe resistance for enrofloxacin .So , it is important for us to adopt the right ways to choose relevant drugs , when we encounter the diseases caused by HPS. |
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| Keywords: | Enrofloxacin Gatifloxacin Ciprofloxacin HPS MIC |
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