| 二氟沙星肺靶向微球制剂的制备 |
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| 引用本文： | 崔琳,李艳华,郑晓星,曹楠,徐志增,苑青艳.二氟沙星肺靶向微球制剂的制备[J].东北农业大学学报,2009,40(12). |
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| 作者姓名： | 崔琳 李艳华 郑晓星 曹楠 徐志增 苑青艳 |
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| 作者单位： | 东北农业大学动物医学学院,哈尔滨,150030 |
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| 基金项目： | 东北农业大学大学生科技创新基金 |
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| 摘 要： | 以可生物降解的明胶为载体,液体石蜡为油相,Span-80为乳化剂,选择正交设计优化空白明胶微球生产工艺,并考察其理化性质,采用乳化交联法制备二氟沙星肺靶向明胶微球。采用紫外可见分光光度计法,测定微球中二氟沙星的含量。结果表明,优选所制的二氟沙星肺靶向明胶微球形态圆整,表面光滑,平均粒径为8.33μm,粒径分布在5.0～25.0μm的微球达到95.71%,二氟沙星明胶微球包封率为62.43%,载药量为13.71%。采用动态分析法研究体外释药特性,二氟沙星明胶微球在12h处药物释放量达到65%,24h内药物释放量达到71%。制备工艺稳定可行,所得二氟沙星明胶微球具有良好的缓释效果。
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| 关 键 词： | 二氟沙星 肺靶向 明胶微球 |
Preparation for lung targeted microsphere of Difloxacin |
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| CUI Lin,LI Yanhua,ZHENG Xiaoxing,CAO Nan,XU Zhizeng,YUAN Qingyan.Preparation for lung targeted microsphere of Difloxacin[J].Journal of Northeast Agricultural University,2009,40(12). |
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| Authors: | CUI Lin LI Yanhua ZHENG Xiaoxing CAO Nan XU Zhizeng YUAN Qingyan |
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| Abstract: | The preparation technology was optimized by odhogonal experimental designed with biodegradable gelatin as the carrier,liquid paraffin as the oilphase,span-80 as the emulsifier,and Difloxacin loaded gelatin microsphere for lung targetting was prepared by the emulsion crosslinking method.Quantitative determination of Difloxacin was carded on by the method of UV spectrephotometry. and the optimal Difloxacin loaded gelatin microsphere was global with smooth surface,The arithmetic mean diameter of microsphere was 8.33 μm with 95.71%of microsphere which are ranging from 5.0 to 25.0 μm,total 62.43% for the encapsulation efficiency,and 13.71%for the drug loading,The release test in vitroshowed that 65% of Difloxacin could release from gelatin micresphere in 12 h and 71% in 24 h with dynamic analysis.The preparation technology is good and stable,and the obtained microsphere can control the release of Difioxacin. |
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| Keywords: | Difloxacin lung targetting gelatin microsphere |
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