| 肠道病原性大肠杆菌和宿主细胞间的相互作用 |
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| 引用本文： | 李正平,杨倩.肠道病原性大肠杆菌和宿主细胞间的相互作用[J].江西农业大学学报,2010,32(1). |
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| 作者姓名： | 李正平 杨倩 |
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| 作者单位： | 南京农业大学,农业部动物生理生化重点开放实验室,江苏,南京,210095 |
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| 基金项目： | 国家自然科学基金(30871858);;教育部博士点基金(B200606);;江苏省支撑计划(BE200830155)资助 |
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| 摘 要： | 肠道病原性大肠杆菌(EPEC)属于胞外菌,主要通过粘附在肠上皮细胞上引起宿主的发病。EPEC形成基座、产生粘附和脱落(A/E)损伤的细菌因子、导致宿主信号转导改变的途径及其发病机制的遗传基础都已经得到广泛的研究。对近年来关于EPEC和宿主细胞间的相互作用的研究进展进行总结,并着重论述EPEC对于肠上皮细胞紧密连接的影响。
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| 关 键 词： | 肠道病原性大肠杆菌 肠上皮细胞 紧密连接 肠上皮细胞屏障 |
The Interaction between Enteropathogenic Escherichia coli and Host Cells |
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| LI Zheng-ping,YANG Qian.The Interaction between Enteropathogenic Escherichia coli and Host Cells[J].Acta Agriculturae Universitis Jiangxiensis,2010,32(1). |
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| Authors: | LI Zheng-ping YANG Qian |
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| Institution: | Key Laboratory of Animal Physiology and Biochemistry/a>;Minstry of Agriculture/a>;Nanjing Agricultural University/a>;Nanjing 210095/a>;China |
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| Abstract: | Enteropathogenic Escherichia coli(EPEC) is an extracellular bacteria,primarily through adhere to host intestinal epithelial cells caused pathogenesis.EPEC can produce pedestals,and the bacterial factors involved in attaching and effacing(A/E) lesion formation,modulates several signal transduction pathways within the host cells and the genetic basis of EPEC pathogenesis have been widely studied.This review describes the recent studies of enteropathogenic(EPEC) interact with host cells,and intensively discuss... |
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| Keywords: | EPEC intestinal epithelial cells tight junctions intestinal epithelial cells barrier |
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