Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement |
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| Authors: | Dalley Jeffrey W Fryer Tim D Brichard Laurent Robinson Emma S J Theobald David E H Lääne Kristjan Peña Yolanda Murphy Emily R Shah Yasmene Probst Katrin Abakumova Irina Aigbirhio Franklin I Richards Hugh K Hong Young Baron Jean-Claude Everitt Barry J Robbins Trevor W |
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| Institution: | Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. jwd20@cam.ac.uk |
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| Abstract: | Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure. Using positron emission tomography, we demonstrated that D2/3 receptor availability is significantly reduced in the nucleus accumbens of impulsive rats that were never exposed to cocaine and that such effects are independent of DA release. These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences. |
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