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The genomic sequence of the accidental pathogen Legionella pneumophila |
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| Authors: | Chien Minchen Morozova Irina Shi Shundi Sheng Huitao Chen Jing Gomez Shawn M Asamani Gifty Hill Kendra Nuara John Feder Marc Rineer Justin Greenberg Joseph J Steshenko Valeria Park Samantha H Zhao Baohui Teplitskaya Elita Edwards John R Pampou Sergey Georghiou Anthi Chou I-Chun Iannuccilli William Ulz Michael E Kim Dae H Geringer-Sameth Alex Goldsberry Curtis Morozov Pavel Fischer Stuart G Segal Gil Qu Xiaoyan Rzhetsky Andrey Zhang Peisen Cayanis Eftihia De Jong Pieter J Ju Jingyue Kalachikov Sergey Shuman Howard A Russo James J |
| Institution: | Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. |
| Abstract: | We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets. |
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