| 芥子酸甲酯氧化偶合合成二聚体酯的研究 |
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| 引用本文： | 陆志科,姚培园.芥子酸甲酯氧化偶合合成二聚体酯的研究[J].中南林业科技大学学报,2007,27(2):57-60. |
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| 作者姓名： | 陆志科 姚培园 |
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| 作者单位： | 广西大学林学院，天津大学药物科学与技术学院 广西南宁530005，天津大学药物科学与技术学院，天津300072，天津300072 |
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| 摘 要： | 在单锅中探讨了以芥子酸为底物,经酯化和氧化偶合两步反应合成芥子酸甲酯二聚体酯的方法.研究结果表明,此合成方法操作简便,反应条件温和(室温反应),无须分离中间体,且产率较高(收率高达66.58%).还探讨了时间、原料比、催化剂的用量等对一锅法产率的影响及氧化偶合机理.
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| 关 键 词： | 芥子酸甲酯 二聚体酯 氧化偶合 合成 |
| 文章编号： | 1673-923X（2007）02-0057-04 |
| 收稿时间： | 2006-06-18 |
| 修稿时间： | 2006-06-18 |
Synthesis of Dimethyl Ester of Thomasidioic Acid by Oxidation Coincidence |
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| LU Zhi-ke,YAO Pei-yuan.Synthesis of Dimethyl Ester of Thomasidioic Acid by Oxidation Coincidence[J].Journal of Central South Forestry University,2007,27(2):57-60. |
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| Authors: | LU Zhi-ke YAO Pei-yuan |
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| Institution: | 1. Forestry College, Guangxi University, Nanning 530005,Guangxi, China; 2.College of Pharmaceuticals and Biotechnology,Tianjin University,Tianjin 300072, China |
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| Abstract: | Using sinapic acid as a raw material,dimethyl ester of thomasidioic acid was synthesized by single-pot reaction method through the procedure of two stages: esterification and oxidation coincidence.Experiment results show that this synthesis had mild reaction conditions(room temperature) and higher yields(yield of 66.58%),avoiding the need to isolate the intermediates.We also discussed such facts as influence the single-pot method: reaction temperature and time,raw material proportion,and quantity of catalysts.The mechanism of oxidation coincidence was discussed in detail. |
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| Keywords: | methyl ester of sinapic acid dimer ester oxidation coincidence synthesis |
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