Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout |
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| Authors: | J P Cravedi A Paris E Perdu-Durand P Prunet |
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| Institution: | (1) INRA, Laboratoire des Xénobiotiques, B.P., 3 180, chemin de Tournefeuille, 31931 Toulouse Cédex, France;(2) INRA, Laboratoire de Physiologie des Poissons, Campus de Beaulieu, 35042 Rennes, France |
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| Abstract: | The effect of GH treatment on hepatic cytochrome P450 content, aryl hydrocarbon hydroxylase (AHH), aminopyrine-N-demethylase (AND), testosterone hydroxylase, testosterone 5 - and 5 -reductase, UDP-glucuronyl transferase (UDPGT) and glutathione S-transferase (GST) activities in immature rainbow trout were investigated. Hepatic cytochrome P450 content, AHH and GST activities were measured in both GH implanted and GH injected animals whereas other activities were assayed in GH implanted trout only.GH implants significantly decreased cytochrome P450 content at 15 days compared to the control but no significant effect was observed at 15 or 30 d when GH was injected biweekly. In both cases, AHH activity was significantly decreased by GH treatment compared to the control whereas GST remained unchanged. Compared to the control, GH implanted fish exhibited a pronounced inhibition of AND, a decreased 6 and 16-testosterone hydroxylation, an inhibition of UDPGT with testosterone as substrate and an enhanced 17-testosterone oxidation. |
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| Keywords: | rainbow trout cytochrome P450 glutathione-transferase glucuronosyl-transferase growth hormone |
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