Research Progress on Drug Resistance and Its Mechanism of Mycoplasma in Livestock and Poultry |
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| Authors: | GONG Xiao-wei MA Wen-ying CHEN Qi-wei ZHENG Fu-ying LIU Yong-sheng |
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| Institution: | State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of the Ministry of Agriculture, Bacterial Diseases in Grazing Animals Team, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China |
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| Abstract: | The harm for livestock and poultry production caused by Mycoplasma infection has got widespread attention of researchers in the world. The practical ways to control the disease in order to reduce economic loss through Mycoplasma infection is the extensive use of antibiotics. Many groups of antibiotics including tetracyclines, macrolides and quinolones have been shown to be effective to Mycoplasma. Clinical practice shows many Mycoplasma isolated from livestock and poultry are characterized not only by single drug resistance but also by multiple antibiotic resistance due to the legacy of past decades of antimicrobial misuse, which threat the livestock and poultry production health. This paper reviews the mechanism of anti-Mycoplasma medicines through the alterations in the targets, the formation of efflux pump system, and the generation of inactivated enzymes of antibiotics, which provide theoretical basis and strategies for establishing resistance testing system, rational drug use and development of new drugs. |
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| Keywords: | livestock and poultry Mycoplasma drug resistance drug-resistant mechanism |
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