|
|||||
|
|
| SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展 | |
| 引用本文： | 周秋格,刘畅,刘玉辉,赖金伦,陈颖钰,郭爱珍,胡长敏.SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展[J].中国畜牧兽医,2016,43(10):2640-2647. |
| 作者姓名： | 周秋格 刘畅 刘玉辉 赖金伦 陈颖钰 郭爱珍 胡长敏 |
| 作者单位： | 1. 华中农业大学动物医学院, 武汉 430070; 2. 农业微生物学国家重点实验室, 武汉 430070 |
| 基金项目： | 国家肉牛/牦牛产业技术体系（nycytx-382662016PY015）；宁夏肉牛呼吸疾病综合征及皮肤病防控技术研究与示范（2012ZDN0903）；中央高校基本科研业务费专项资金（2662015PY054）；湖北省自然科学基金项目（2015CFB435） |
| 摘 要： | 单免疫球蛋白白介素1受体相关蛋白（SIGIRR）是TIR超家族成员，最新研究表明它可负性调节IL-1R/TLRs受体介导的固有免疫应答，且在感染性疾病、肿瘤及自体免疫病诱导的炎症反应调节上所起的重要作用已经被阐明。作者主要综述了SIGIRR基因和蛋白表达模式在人、小鼠、牛等物种间的差异性，因其结构特异性所具有的对IL-1R/TLRs炎性信号通路的负性调控和具体的调控机理，以及在不同炎性相关疾病的发生和发展中抑制炎性反应的机制，进而为临床的炎性相关疾病治疗提供理论借鉴，同时也拓宽了SIGIRR基因在动物疾病治疗中的应用范围。 |
| 关 键 词： | SIGIRR TLRs 信号通路 负性调控 |
| 收稿时间： | 2016-03-01 |
Research Progress on the Negative Regulatory Function of SIGIRR to IL-1R/TLRs Signal Pathway |
|
| ZHOU Qiu-ge,LIU Chang,LIU Yu-hui,LAI Jin-lun,CHEN Ying-yu,GUO Ai-zhen,HU Chang-min.Research Progress on the Negative Regulatory Function of SIGIRR to IL-1R/TLRs Signal Pathway[J].China Animal Husbandry & Veterinary Medicine,2016,43(10):2640-2647. | |
| Authors: | ZHOU Qiu-ge LIU Chang LIU Yu-hui LAI Jin-lun CHEN Ying-yu GUO Ai-zhen HU Chang-min |
| Institution: | 1. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; 2. State Key Laboratory of Agricultural Microbiology, Wuhan 430070, China |
| Abstract: | Single immunoglobulin IL-1 related receptor (SIGIRR) is a member of TIR superfamily.Recent evidences suggested that it could negatively modulate ILRs/TLRs-mediated innate immune response,and in particular its important role focused from infectious and intestinal inflammation to autoimmunity or cancer-related inflammation had been illuminated.Here,we summarized our current understanding of the expression patterns of SIGIRR gene and protein in different specises including human,mouse and bovine,its downregulate function of the IL-1/TLRs singal pathway and specific negative regulation mechanism ascribed to its structure specificity,and also its elaborate regulating process related to the occurrence and development of different pathogen condition.And then it can not only provide theoretical references for clinical inflammatory related disease,but also broaden the application scope of SIGIRR gene in the treatment of animal diseases. |
| Keywords: | SIGIRR TLRs signal path negative regulation |
| 本文献已被 CNKI 等数据库收录！ | |
| 点击此处可从《中国畜牧兽医》浏览原始摘要信息 | |
| 点击此处可从《中国畜牧兽医》下载免费的PDF全文 | |