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| 黄芪多糖注射液对猪瘟耐热保护剂活疫苗在兔体内免疫效果的影响 | |
| 引用本文： | 朱辉,沈志强,王振勇,马霞,郭振环.黄芪多糖注射液对猪瘟耐热保护剂活疫苗在兔体内免疫效果的影响[J].中国畜牧兽医,2011,38(7):66-70. |
| 作者姓名： | 朱辉 沈志强 王振勇 马霞 郭振环 |
| 作者单位： | 1. 山东农业大学动物科技学院,山东泰安271000;山东省滨州畜牧研究院,山东滨州 256600 2. 山东农业大学动物科技学院,山东泰安271000;山东省滨州畜牧研究院,山东滨州 256600;山东绿都生物科技有限公司,山东滨州256600 3. 山东农业大学动物科技学院,山东泰安,271000 4. 山东省滨州畜牧研究院,山东滨州,256600 |
| 摘 要： | 试验旨在研究黄芪多糖(astragalus polysaccharide,APS)注射液作为猪瘟疫苗稀释液及黄芪多糖作为疫苗佐剂提供数据支持。用1%的黄芪多糖注射液、猪瘟疫苗专用稀释液、生理盐水3种不同猪瘟疫苗稀释液稀释兔源猪耐热保护剂活疫苗免疫兔体,比较免疫后不同时间段内血液中的淋巴细胞的活性及血清中的猪瘟抗体、白介素2(interleukin 2,IL-2)、白介素6(interleukin 6,IL-6)、γ干扰素(interferon γ,IFN-γ)、新蝶呤(neopterin,Npt)水平,综合评价3种不同猪瘟疫苗稀释液对兔源猪瘟耐热保护剂活疫苗在兔体内免疫效果的影响。结果表明,黄芪多糖能不同程度的提高抗体水平和多种细胞因子的含量。因此,黄芪多糖注射液可以作为猪瘟疫苗稀释液或改良现有猪瘟疫苗稀释液,黄芪多糖也可以作为猪瘟疫苗佐剂。 |
| 关 键 词： | 黄芪多糖 淋巴细胞活性 抗体 白介素 干扰素 新蝶呤 |
| 收稿时间： | 2010-12-31 |
Effects of APS Injection to Activated Thermostabilized Vaccine of Swine Fever in Rabbit |
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| ZHU Hui,SHEN Zhi-qiang,WANG Zhen-yong,MA Xia,GUO Zhen-huan.Effects of APS Injection to Activated Thermostabilized Vaccine of Swine Fever in Rabbit[J].China Animal Husbandry & Veterinary Medicine,2011,38(7):66-70. | |
| Authors: | ZHU Hui SHEN Zhi-qiang WANG Zhen-yong MA Xia GUO Zhen-huan |
| Institution: | 1. College of Animal Science, Shandong Agricultural University, Taian 271000,China;2. Shandong Province Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600,China;3. Shandong Lvdu Biotechnology Co., Ltd., Binzhou 256600,China |
| Abstract: | To provide the basis of APS used for swine fever vaccine diluent and vaccine adjuvant. The rabbits in three groups were intramuscular injected with activated thermostabilized vaccine of swine fever with diluent of 1% astragalus polysaccharide (astragalus polysaccharide,APS) injection, dedicated diluent for swine fever vaccine and physiological saline respectively. After vaccination, the activty of lymphocyte, antibody of swine fever in serum and contents of interleukin 2, interleukin 6, interferon γ and neopterin were determined to evaluate the impact of these three diluents on vaccination effects to swine fever vaccine.The results showed that APS raised contents of antibody of swine fever in serum and some cell factors. APS could be used for swine fever vaccine diluent or improved diluent and swine fever vaccine adjuvant. |
| Keywords: | astragalus polysaccharide activity of lymphocytes antibody interleukin interferon Neopterin |
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