| 猪链球菌2型在家兔体内的分布及致病性 |
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| 引用本文： | 胡东波,何孔旺,倪艳秀,俞正玉,吕立新,周俊明,茅爱华,范红结.猪链球菌2型在家兔体内的分布及致病性[J].中国兽医学报,2011,31(6). |
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| 作者姓名： | 胡东波 何孔旺 倪艳秀 俞正玉 吕立新 周俊明 茅爱华 范红结 |
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| 作者单位： | 1. 江苏省农业科学院兽医研究所,江苏南京,210014
2. 南京农业大学动物医学院,江苏南京,210095 |
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| 基金项目： | 国家“973”计划资助项目(2006CB504403); 公益性行业(农业)科研专项(200803016-01); 江苏省自然科学基金资助项目(BK2009327) |
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| 摘 要： | 用猪链球菌2型SS2-1株按109 CFU/只分别以静脉、肌肉、皮下、滴鼻、口服5种途径人工感染健康家兔,结果前4种感染途径均可引起发病并死亡,口服不发病,且以静脉感染发病最急。当分别静脉注射109,108,107,106,105 CFU/只SS2-1株,肌肉注射108,106 CFU/只SS2-1株,结果证实感染剂量与发病程度有正相关性,家兔临床症状和病理变化明显。用荧光定量PCR方法检测所有感染家兔组织的含菌量,结果提示发病程度与含菌量呈正相关,且各组织含菌量有差异。另外,人工感染家兔后在不同时间点取动物组织做菌体含量动态监测,结果提示体内含菌量随时间推移递增,发病高峰或死亡时达最高值。试验结果证明SS2-1株对家兔易感,致病性稳定,且细菌在动物体内增殖稳定并具有规律性。
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| 关 键 词： | 家兔 猪链球菌2型 人工感染 致病性 |
Pathogenicity and distribution of SS2 in tissues and organs of rabbits after artificial infection |
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| HU Dong-bo,HE Kong-wang,NI Yan-xiu,YU Zheng-yu,LU Li-xin,ZHOU Jun-ming,MAO Ai-hua,FAN Hong-jie.Pathogenicity and distribution of SS2 in tissues and organs of rabbits after artificial infection[J].Chinese Journal of Veterinary Science,2011,31(6). |
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| Authors: | HU Dong-bo HE Kong-wang NI Yan-xiu YU Zheng-yu LU Li-xin ZHOU Jun-ming MAO Ai-hua FAN Hong-jie |
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| Institution: | HU Dong-bo1,HE Kong-wang1,NI Yan-xiu1,YU Zheng-yu1,LU Li-xin1,ZHOU Jun-ming1,MAO Ai-hua1,FAN Hong-jie2(1.Institute of Veterinary Medicine of Jiangsu Academy of Agricultural Science,Nanjing 210014,China,2.College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | The healthy rabbits were infected with 109 CFU SS2-1 by intravenous,intramuscular,subcutaneous injection,cavitas nasi and oral.The first four groups can cause onset or death while the last one didn't cause the disease.The rabbits infected by intravenous injection were the mose severity;The rabbits was infected with 109,108,107,106,105 CFU SS2-1 by intravenous injection and 108,106 CFU SS2-1 by intramuscular injection,and all the rabbits got onset and some died,indicating that infection dose and morbility ha... |
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| Keywords: | rabbit Streptococcus suis serotype 2 artifical infection pathogenicity |
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