COLLAGENASE CHEMONUCLEOLYSIS—A LONG TERM RADIOGRAPHIC STUDY IN NORMAL DOGS |
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| Authors: | Matthew AO Atilola DVM PhD Joanne R Cockshutt DVM MS Ron Mclaughlin DVM DVSc Susan M Cochrane DVM DVSc Paul W Pennock DVM MS |
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| Institution: | Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario NIG 2W1. |
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| Abstract: | Five clinically normal five year old dogs were used in this study. From a randomised table inter ver tebral discs were each injected with either collagenase or calcium chloride diluent. The surgically exposed cervical discs were injected with 50 units whereas thoracic and lumbar discs were injected under fluoroscopic guidance with 100 units of the enzyme. Postinjection radiographs revealed significant (p ≤ .05) disc space narrowing in enzyme injected discs. The cervical discs had the highest frequency of radiographic narrowing (87%) followed by the thoracic (70%) and lumbar (53%) discs. Spondylosis deformans developed at the sites of cervical enzyme injections. None of the dogs had neurologic abnormalities one year postinjection. |
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| Keywords: | collagenase chemonucleolysis (canine) |
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