Change in intrarenal Ghrelin expression in immune complex-mediated glomerular
disease in dogs |
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| Authors: | Akira YABUKI Keijiro MIZUKAMI Satoshi TOKUNAGA Osamu YAMATO |
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| Institution: | 1)Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan;2)Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1–21–24, Kagoshima 890–0065, Japan |
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| Abstract: | Ghrelin is a peptide hormone that is mainly produced by the stomach. The kidney is a
major source of local ghrelin, and maintaining body fluid balance is considered a critical
role of renal ghrelin. However, there are no reports on renal ghrelin in small animal
medicine. The present study investigated the intrarenal localization of and change in
ghrelin expression in dogs with immune complex-mediated glomerulonephritis (ICGN). Ghrelin
immunoreactivity (IR) was observed in the distal tubules of normal kidneys. Ghrelin IR was
weak in ICGN kidneys, and the quantitative ghrelin IR score was significantly lower in
ICGN kidneys than in normal kidneys. In cases of ICGN, plasma creatinine concentrations
showed a positive correlation with the ghrelin IR score. |
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| Keywords: | canine ghrelin glomerular disease immune complex-mediated nephritis immunohistochemistry |
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