Anethole inhibits growth of recently emerged multidrug resistant toxigenic
Vibrio cholerae O1 El Tor variant strains in
vitro |
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| Authors: | M Shamim Hasan ZAHID Sharda Prasad AWASTHI Atsushi HINENOYA Shinji YAMASAKI |
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| Institution: | 1)Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598–8531, Japan |
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| Abstract: | To search natural compounds having inhibitory effect on bacterial growth is important,
particularly in view of growing multidrug resistant (MDR) strains of bacterial pathogens.
Like other bacterial pathogens, MDR Vibrio cholerae, the causative agent
of diarrheal disease cholera, is becoming a great concern. As an approach of searching new
antimicrobial agents, here, we show that anethole, a well-studied natural component of
sweet fennel and star anise seeds, could potentially inhibit the growth of MDR O1 El Tor
biotype, the ongoing 7th cholera pandemic variant strains of toxigenic V.
cholerae. The minimum inhibitory concentration (MIC) of anethole against
diverse O1 El Tor biotype strains is evaluated as 200
µg/ml. Moreover, the effect of anethole is
bactericidal and exerts rapid-killing action on V.
cholerae cells. This study is the first report which demonstrates
that anethole, purified from natural compound, is a potent inhibitor of growth of
toxigenic V. cholerae. Our data suggest that anethole could be a
potential antimicrobial drug candidate, particularly against MDR V.
cholerae mediated infections. |
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| Keywords: | anethole El Tor variant multidrug resistant natural compounds Vibrio cholerae |
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